ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Review Tumour Necrosis Factor: A New Mediator in Coronary Ischemic Syndromes [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1995; 23(5): 380-383

Review Tumour Necrosis Factor: A New Mediator in Coronary Ischemic Syndromes

Mehmet Emin KORKMAZ1, Hamide KART1, Haldun MÜDERRİSOĞLU1

Tumour necrosis factor (TNF-Å) is a polypeptide (MW 17 kDa) secreted from reticuloendothelial cells in response to a wide variety of inflammatory and infectious stimuli. After bonding with its specific receptor, activation of G protein system and various protein kinases take place and this causes its ubiquitous biological effects in different types of tissues. TNF-Å has important roles in cachexia, endotoxic shock, coagulation, immunity, ischemia and reperfusion. TNF-Å, by causing the activation of important adhesion molecules, leukocytes and platelet activating factor, may aggravate and shapen the ischemic process. The increase of its serum level after acute myocardial infarction and other animal models further supports the notion that TNF-Å has an important role in myocardial ischemia. In this brief review biologic effects of TNF-Å, its possible role in ischemic syndromes. With special reference to myocardial ischemia, are described.

Keywords: Tümör nekroz faktörü, miyokard iskemisi

How to cite this article
Mehmet Emin KORKMAZ, Hamide KART, Haldun MÜDERRİSOĞLU. Review Tumour Necrosis Factor: A New Mediator in Coronary Ischemic Syndromes. Turk Kardiyol Dern Ars. 1995; 23(5): 380-383
Manuscript Language: Turkish


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