ISSN 1016-5169 | E-ISSN 1308-4488
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Comparison of Meteorin-like Protein Infusion vs. Moderate-Intensity Exercise on Cardiac Mast Cell and Plasma Cell Dynamics and Musclin Levels in Female Rats [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-80886 | DOI: 10.5543/tkda.2025.80886

Comparison of Meteorin-like Protein Infusion vs. Moderate-Intensity Exercise on Cardiac Mast Cell and Plasma Cell Dynamics and Musclin Levels in Female Rats

Nazife Ülker Ertuğrul1, Ebru Gökdere2, Feyza Keskin3, Nurcan Delice3, Tuğrul Ertuğrul3, Gökçen Sevilgen4, Şerife Tütüncü3, Sinan Canpolat2
1Department of Physiology, Faculty of Medicine, Samsun University, Samsun, Türkiye
22Department of Physiology, Faculty of Medicine, Firat University, Elazig, Türkiye
3Department of Histology and Embryology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Türkiye
4Department of Thoracic Surgery, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Türkiye


OBJECTIVE
Moderate-intensity exercise modulates the immunological response in cardiac tissue. Meteorin-like protein (metrnl) is a myokine secreted by muscle cells during exercise and is involved in immune response regulation. However, the effects of metrnl on mast cells and plasma cells in cardiac tissue are not fully understood. This study was designed to assess the effects of exogenous metrnl infusion on the cardiac mast cells and plasma cells. In addition, serum levels of musclin, an exercise-responsive factor, were evaluated during the effects of moderate-intensity exercise on cardiac immune cells.

METHOD
Twenty-seven female rats were randomly divided into three groups (n=9 each): control (deionized water), exercise (moderate-intensity swimming exercise) and metrnl (1 µg/day). For histological studies, hematoxylin-eosin, toluidine blue and methyl green-pyronin staining were performed on heart tissues. Musclin levels were measured in serum samples using the ELISA method.

RESULTS
Metrnl infusion increased cardiac mast cell and plasma cell numbers in female rats like moderate-intensity exercise. In addition, the increase in cardiac mast cell count was greater in the exercise group, whereas musclin concentration decreased in female rats subjected to moderate-intensity exercise.

CONCLUSION
Our data suggests that moderate-intensity exercise’s effects on the cardiac immune system may be mediated, by downregulating musclin and metrnl-dependent upregulating cardiac mast cells and plasma cells. Thus, exercise-induced metrnl may affect the cardiac immune response by modulating cardiac immune cells.

Keywords: Exercise, heart, mast cell, meteorin-like protein, musclin (osteocrin), plasma cell

Corresponding Author: Nazife Ülker Ertuğrul
Manuscript Language: English
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