ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Gender-Dependent Comparison of Coronary Computed Tomography Angiographic Characteristics among Patients with Suspected Atherosclerosis: A Single-Center Experience [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(1): 22-31 | DOI: 10.5543/tkda.2022.75572

Gender-Dependent Comparison of Coronary Computed Tomography Angiographic Characteristics among Patients with Suspected Atherosclerosis: A Single-Center Experience

Aslan Erdoğan1, Eyup Özkan1, Mehmet Rasih Sonsöz1, Ömer Genç1, Ersin Ibişoğlu1, Yelda Özateş1, Duygu Inan1, Muhammed Mert Göksu1, Yiğit Can Kartal2, Ali Fuat Tekin2, Berk Erdinç1, Gazi Çapar1, Ahmet Güler1, Alev Kılıçgedik1, Ali Karagöz3
1Clinic of Cardiology, Çam and Sakura Training and Research Hospital, Istanbul, Türkiye
2Clinic of Radiology, Çam and Sakura Training and Research Hospital, Istanbul, Türkiye
3Clinic of Cardiology,Kartal Kosuyolu Training and Research Hospital,Istanbul, Türkiye


OBJECTIVE
In this study, we aimed to examine gender-based differences in coronary artery disease (CAD) risk factors, the presence and severity of atherosclerosis, and the distribution of plaque type in patients presenting with chest pain.


METHODS
A total of 1496 patients who applied to our cardiology outpatient clinic with chest pain and underwent computed coronary tomographic angiography (CTA) between August 2020 and October 2021 were included in the study. Plaque characteristics, Agatston score, and Coronary Artery Disease-Reporting and Data System (CAD-RADS) score obtained from the patients’ CTAs were compared by gender.


RESULTS
Of the 1496 patients evaluated, 47.9% were female. Coronary atherosclerosis was detected in 35.4% of females and 52.9% of males (P <0.001). Diabetes mellitus [155 (21.8%) vs. 123 (15.7%); P <0.001] and hypertension [271 (38.1%) vs. 249 (32%); P <0.001] rates were higher in females than in males. Plaque burden and high-risk plaque rate were found to be higher in males (P <0.001). Next, the rate of moderate-to-high coronary artery stenosis (CAD-RADS ≥3) was observed at 21.6% in men and 12.2% in women (P <0.001). Agatston score was found to be higher in males than in females for all age groups (P <0.001). The severity of CAD increased sharply with age in females (P interaction = 0.003).


CONCLUSION
Although female patients demonstrated higher rates of traditional risk factors, the male gender was associated with increased coronary plaque burden, high-risk plaque, CADRADS, and Agatston scores. Therefore, patient-based approaches that consider gender-related differences could provide effective treatment and follow-up.

Keywords: Atherosclerosis, coronary artery disease severity, coronary ct angiography, coronary plaque characterization, sex-specific coronary artery disease

How to cite this article
Aslan Erdoğan, Eyup Özkan, Mehmet Rasih Sonsöz, Ömer Genç, Ersin Ibişoğlu, Yelda Özateş, Duygu Inan, Muhammed Mert Göksu, Yiğit Can Kartal, Ali Fuat Tekin, Berk Erdinç, Gazi Çapar, Ahmet Güler, Alev Kılıçgedik, Ali Karagöz. Gender-Dependent Comparison of Coronary Computed Tomography Angiographic Characteristics among Patients with Suspected Atherosclerosis: A Single-Center Experience. Turk Kardiyol Dern Ars. 2023; 51(1): 22-31

Corresponding Author: Aslan Erdoğan, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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