ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Relation of CMV Infection with an Inflammation Marker CRP in Coronary Heart Disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1999; 27(9): 610-614

Relation of CMV Infection with an Inflammation Marker CRP in Coronary Heart Disease

H. Asuman KAFTAN1, Osman KAFTAN2, Mustafa KILI«1
1
2

Whether the human cytomegalovirus plays a causal role in atlżerosc l e rosis etiology is controversial. We conducted a case-control study to investigate whether previous infection with cytomegalovirus is associated with coronary heart disease and markers of systemic inflammation, because systemic inflammation also may play a role in atherosclerosis. We also studied the correlation between anticytomegalovirus antibody titer and coronary artery disease. 150 cases (45 female, mean age, 58,7 Ī 7,6 years) with a documented coronary heart disease anel 160 vol unteer control ca ses (50 female, m ean age 57,82 Ī 8,1 years) were studied. Cytomegalovirus serology was performed to determine presence of specific IgG antibodies and titers of the anticytomegalovirus antibodies. In addition, C-reactive protein levels were determined in each case. The prevalence of specific antibodies to cytomegalovirus was 57,3% in the ptaient groups, 56% among the controls (p=0,39). But high anti -cytożnegalovirus titer (~ 1 :800) was seen in the patient group w ith a higher ineidence (26,6% versus 10%, p=O,OOO). Mean value of C-reactive protein was higher in the patient group (2,99 Ī 0,92 mg/L, versus 1,79 Ī 0,51 żng/L, p=O,OOO), and there was a linear correlation with the high antibody titer and the level of Creactive protein (r=0,35, p=O,OOO). These findings support that, instead of the seropositivity of the population, the titer of anti cytomegalovirus lgG antibody and the levels of Creactive protein may predict coronary artery disease.

Keywords: Coronary artery disease, infections, cytomegalovirus, C-reative protein

How to cite this article
H. Asuman KAFTAN, Osman KAFTAN, Mustafa KILI«. Relation of CMV Infection with an Inflammation Marker CRP in Coronary Heart Disease. Turk Kardiyol Dern Ars. 1999; 27(9): 610-614
Manuscript Language: Turkish


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