ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Antihypertensive Efficacy Of Nebivolol And Low Dose Spironolactone In Patients With Resistant Hypertension [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(6): 381-386 | DOI: 10.5543/tkda.2023.60464

Antihypertensive Efficacy Of Nebivolol And Low Dose Spironolactone In Patients With Resistant Hypertension

Hamdi Püşüroğlu1, Ender Özal2, Ahmet Yaşar Çizgici3, Yalçın Avcı3, Ali Rıza Demir3, İsmail Bıyık4
1Department of Cardiology, Çam and Sakura Başak City Training and Research Hospital, Istanbul, Türkiye
2Bağcılar Training and Research Hospital, Istanbul, Türkiye
3Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Türkiye
4Department of Cardiology, Usak University Training and Research Hospital, Usak, Türkiye


OBJECTIVE
Resistant hypertension is associated with increased mortality and morbidity. The optimal medical therapy is not fully elucidated in resistant hypertension. There are relatively few studies in the literature on the treatment of resistant hypertension. In this study, we compared the effectiveness of nebivolol 5 mg, a third generation beta-blocker, with spironolactone 25 mg in patients with resistant hypertension.


METHODS
A total of 81 patients with resistant hypertension were included in the study. The spironolactone group was composed of 38 patients while the nebivolol group was composed of
43 patients. Resistant hypertension was defined as having office blood pressure ≥ 140/90 mmHg while the patients were under 3 or more antihypertensive agents treatment which included diuretic agents. Office and ambulatory blood pressure at basal and after 8 weeks of treatment were recorded.


RESULTS
Office systolic blood pressure and diastolic blood pressure in 24-hour ambulatory blood  pressure monitoring were significantly lower when compared to basal values in both nebivolol and spironolactone groups. The decrease in 24-hour mean systolic and diastolic blood pressure in nebivolol group was 14.9 ± 19.8 mmHg and 9.3 ± 12.7 mmHg compared to 19.5 ± 16.4 mmHg and 13.7 ± 10.8 mmHg in the spironolactone group, respectively. The decrease in 24-hour mean systolic and diastolic blood pressure was not significantly different
between the nebivolol and spironolactone groups (P = 0.338 and P = 0.153).


CONCLUSION
Nebivolol is an effective treatment option for resistant hypertension and the antihypertensive effect of nebivolol is similar to low-dose spironolactone.

Keywords: Ambulatory blood pressure monitoring, nebivolol, resistant hypertension, spironolactone

How to cite this article
Hamdi Püşüroğlu, Ender Özal, Ahmet Yaşar Çizgici, Yalçın Avcı, Ali Rıza Demir, İsmail Bıyık. Antihypertensive Efficacy Of Nebivolol And Low Dose Spironolactone In Patients With Resistant Hypertension. Turk Kardiyol Dern Ars. 2023; 51(6): 381-386

Corresponding Author: Ender Özal, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 Archives of the Turkish Society of Cardiology



Kare Publishing is a subsidiary of Kare Media.