Archives of the Turkish Society of Cardiology
Colchicine in the Treatment of Postpericardiotomy and Other Acute Pericarditis [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1993; 21(3): 165-168

Colchicine in the Treatment of Postpericardiotomy and Other Acute Pericarditis

Hüsniye YÜKSEL1, Gülgün GÖKTUNA1, Ahmet SERT1, Sinan ÜNER1, Cem DEMİROĞLU1

Colchicine is an antiinflammatory agent used in the treatment of gout arthritis. It has been advocated in disorders associated with inflammation and subsequent fibrosis since it inhibitis collagen synthesis and secretion, and enhances collagenase activity. We used colchicine to evaluate the efficacy in 15 patients (9 men and 6 women between the ages of 23 and 60, with a mean age of 44) unresponsive to nonsteroidal antiinflammatory therapy. Pericarditis was due to postpericardiotomy syndrome in 10 patients. Dressler syndrome in 2, tuberculosis in 1. The remaining two were termed idiopathic. The drug was given 3 mg/d in the first day. 2 mg/d in the second day as a loading dose and 1 mg/d subsequently for 8 weeks as maintenance. Favorable results were obtained in all cases except in one patient with tuberculous pericarditis. Because of its potent antiinflammatory effect, colchicine may be used in the treatment of idiopathic or immunologicallymediated pericarditis as a drug of choice. However, this should be confirmed by comparative studies done with colchicine vs nonsteroidal antiinflammatory drugs.

Keywords: Postperikardioto syndrome, pericarditis, colchicine

How to cite this article
Hüsniye YÜKSEL, Gülgün GÖKTUNA, Ahmet SERT, Sinan ÜNER, Cem DEMİROĞLU. Colchicine in the Treatment of Postpericardiotomy and Other Acute Pericarditis. Turk Kardiyol Dern Ars. 1993; 21(3): 165-168
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