Archives of the Turkish Society of Cardiology
Successful lysis of a mobile left ventricular thrombus by slow infusion of low-dose tissue plasminogen activator [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2010; 38(7): 489-491

Successful lysis of a mobile left ventricular thrombus by slow infusion of low-dose tissue plasminogen activator

Yılmaz Güneş, Yemlihan Ceylan, Mustafa Tuncer
Department of Cardiology, Yuzuncu Yil University, Van, Turkey

There is no consensus on the management of intracardiac mural thrombi. A 59-year-old man underwent echocardiographic examination for right leg pain and pulse deficits in the right lower extremity, which showed severe left ventricular systolic dysfunction and a bell-shaped protruding mobile thrombus in the left ventricular apex. Due to high risk of surgery, 50 mg recombinant tissue-type plasminogen activator (rt-PA) was slowly infused over eight hours. Serial echocardiographic examinations showed a progressive decrease in the size of the thrombus within the first hours of rt-PA infusion, resulting in complete lysis after 24 hours. Low-dose and slow-infusion thrombolytic therapy may be an alternative therapy for left ventricular thrombi when surgery is not feasible.

Keywords: Echocardiography, thrombolytic therapy/methods, thrombosis/drug therapy, tissue plasminogen activator/therapeutic use

How to cite this article
Yılmaz Güneş, Yemlihan Ceylan, Mustafa Tuncer. Successful lysis of a mobile left ventricular thrombus by slow infusion of low-dose tissue plasminogen activator. Turk Kardiyol Dern Ars. 2010; 38(7): 489-491

Corresponding Author: Yılmaz Güneş, Türkiye
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