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Archives of the Turkish Society of Cardiology
Thyroid Functions Are Associated with All-Cause Long-Term Mortality in Elderly Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(6): 387-393 | DOI: 10.5543/tkda.2023.53389

Thyroid Functions Are Associated with All-Cause Long-Term Mortality in Elderly Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Ender Emre1, Kaan Hancı2, Mustafa Doğuş Gökçek3, Müjdat Aktaş4, Ezgi Kalaycıoğlu1, Mustafa Çetin5, Kurtuluş Karaüzüm3, İrem Karaüzüm3, Ertan Ural3
1Departments of Cardiology, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Türkiye
2Departments of Cardiology, Akçaabat Haçkalı Baba State Hospital, Trabzon, Türkiye
3Department of Cardiology, Kocaeli University Medical Faculty, Kocaeli, Türkiye
4Department of Cardiology, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Türkiye
5Medical Faculty, Department of Cardiology, Recep Tayyip Erdoğan University, Rize, Türkiye


OBJECTIVE
Our aim in this study was to show the relationship between long-term all-cause mortality and thyroid functions in the elderly patient group that underwent primary percuta-neous coronary intervention with the diagnosis of ST-segment elevation myocardial infarction.


METHODS
Two-hundred seventy patients over 65 years of age who underwent primary percutaneous coronary intervention with the diagnosis of ST-segment elevation myocardial infarction were analyzed retrospectively. After applying the exclusion criteria, 198 patients were included in the study. The patients were divided into 2 groups according to their out-of-hospital mortality status. Angiographic, laboratory, echocardiographic, and electrocardiographic data were analyzed.


RESULTS
The mean age of 198 patients in the study was 72.5 ± 6.6 years, and the median follow-up time was 101.7 months. Age was higher in the deceased group (70.4 ± 5.4 vs. 74.5 ± 6.9, P < 0.001). In multivariate analysis, age (odds ratio: 1.59, P = 0.003), insulin (odds ratio: 2.561, P = 0.016), angina balloon time (odds ratio: 1.134, P = 0.002), number of serious stenoses (odds ratio: 1.702, P = 0.003), creatinine (odds ratio: 3.043, P < 0.001), and fT4 (odds ratio: 2.026, P = 0.026) were determined as independent predictors of mortality. The fT4 level was correlated with the uric acid level (R: 0.182, P = 0.02) and the fT3 level was correlated with albumin (R: –0.253, P = 0.001) and creatinine (R: –0.224, P = 0.003) levels. A fT4 level cutoff value of 0.99 ng/mL had a sensitivity of 76%, a specificity of 54%, and an area under the curve of 0.675 in predicting mortality. In Kaplan–Meier analysis, fT4 elevation was strongly associated with mortality (P = 0.01).


CONCLUSION
In our study, subclinical values in thyroid functions were found to be associated with increased mortality, apart from known factors in elderly patients who underwent primary PTCA with the diagnosis of ST-segment elevation myocardial infarction.

Keywords: Elderly, mortality, STEMI, thyroid

How to cite this article
Ender Emre, Kaan Hancı, Mustafa Doğuş Gökçek, Müjdat Aktaş, Ezgi Kalaycıoğlu, Mustafa Çetin, Kurtuluş Karaüzüm, İrem Karaüzüm, Ertan Ural. Thyroid Functions Are Associated with All-Cause Long-Term Mortality in Elderly Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Turk Kardiyol Dern Ars. 2023; 51(6): 387-393

Corresponding Author: Ender Emre, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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