Archives of the Turkish Society of Cardiology
Effect of Trimetazidine on Myocardial Contractile Protein Troponin-T Destruction During Coronary Bypass Grafting [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1999; 27(7): 496-500

Effect of Trimetazidine on Myocardial Contractile Protein Troponin-T Destruction During Coronary Bypass Grafting

Bülent TÜNERİR1, Sadettin DERNEK1, Yavuz BEŞOĞUL1, Ömer ÇOLAK1, Özkan ALATAŞ1, Tuğrul KURAL1, Recep ASLAN1

The aim of the present study was to evaluate the effect of trimetazidine (TMZ) on destruction of human ınyocardial contractile protein troponin-T during ischemia and reperfusion. The study was carried out on 30 patients undergoing aorto-coronary bypass surgery randomized to the TMZ group (composed of 15 patients) and the placebo group ( 15 patients) in NYHA Class III-IV Pretreatment was started three weeks before surgery with trimetazidine (60 mg orally per day) or placebo. In the TMZ group , there were 2 women and 13 men with a mean age of 57.1±2.2 and mean cross daınping time of 44±1.8 minutes. The placebo group, comprised 5 women and 10 men with a mean age of 58,4±1.2 and a mean cross clamping time of 42±2.4 minutes. Serial blood samples were collected before and after surgery for measure of serum concentrations of cardiac troponin-T. The preoperative serum concentration of TnT was measured 0-0.04 ng/ml in all patients whereas mean Troponin T levels were measured at 5 minutes after reperfusion (1.5±0.3ng/ml), 12h after surgery (ı .4±0. ıng/ml) and 24h after surgery (0.9±0. ıng/m l) and 48h. after surgery (0. ı ±0. ıng/ml) in the TMZ group. TnT levels of the placebo group measured at the same time periods were 4.4±0.4ng/ml, 4.8±0.7ng/ml, 2.8±0.4ng/ml and 0.7±0.lng/ml, respectively. In the TMZ group, TnT levels were significantly lower than those in the placebo group (pKeywords: Trimetazidine, cardiac troponin T, reperfusion injury, myocardial protection


How to cite this article
Bülent TÜNERİR, Sadettin DERNEK, Yavuz BEŞOĞUL, Ömer ÇOLAK, Özkan ALATAŞ, Tuğrul KURAL, Recep ASLAN. Effect of Trimetazidine on Myocardial Contractile Protein Troponin-T Destruction During Coronary Bypass Grafting. Turk Kardiyol Dern Ars. 1999; 27(7): 496-500
© Copyright 2020 Archives of the Turkish Society of Cardiology
LookUs & Online Makale