ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Effect of Allopurinol on Myocardial Recovery During Reperfusion [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1992; 20(4): 260-263

Effect of Allopurinol on Myocardial Recovery During Reperfusion

Y.Halim SONCUL1, Levent GÖKGÖZ1, Sedat KALAYCIOĞLU1, Volkan SİNCİ1, Melih KAPTANOĞLU1, Ali YENER1, Ali ERSÖZ1

A comparative study on isolated guinea pig hearts was carried out to determine the effect of allopurinolol-added reperfusion solution on myocardial recovery after global ischemia. After 20 minutes of normothermic ischemia two groups of solutions (1- Krebbs Solution 2- Krebsbs Solution + Allopurinol 1 mmol/L) were used for reperfusion (10 animals for each group). Postischemic myocardial functions (heart rate, ventricular contractility and heart work) and tissue enzymes (CK-MB, LDH) were compared with their preischemic values. Addition of allopurinol 1 mmol/L to reperfusion solution improved postischemic myocardial functions and decreased myocardial injury.


How to cite this article
Y.Halim SONCUL, Levent GÖKGÖZ, Sedat KALAYCIOĞLU, Volkan SİNCİ, Melih KAPTANOĞLU, Ali YENER, Ali ERSÖZ. Effect of Allopurinol on Myocardial Recovery During Reperfusion. Turk Kardiyol Dern Ars. 1992; 20(4): 260-263
Manuscript Language: Turkish


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Journal Citation Indicator: 0.18
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