Archives of the Turkish Society of Cardiology
Evaluation of statin use on LDL cholesterol levels in Turkey: A systematic review [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2020; 48(2): 137-148 | DOI: 10.5543/tkda.2019.45156

Evaluation of statin use on LDL cholesterol levels in Turkey: A systematic review

Pınar Kızılırmak1, Zeki Öngen2, Meral Kayıkçıoğlu3, Lale Tokgözoğlu4
1Amgen Turkey, Medical Department, Istanbul, Turkey
2Istanbul University Cerrahpasa Faculty of Medicine, Cardiology Department, Istanbul, Turkey
3Ege University Faculty of Medicine, Cardiology Department, Izmir, Turkey
4Hacettepe University Faculty of Medicine, Cardiology Department, Ankara, Turkey


OBJECTIVE
The aim of this study was to examine and present the effect of statin treatment on the low-density lipoprotein (LDL) cholesterol level of patients in Turkey by evaluating the data of studies conducted in the country.

METHODS
Manuscripts published between January 1, 2008 and December 31, 2017 with terms ‘LDL’ and ‘TURK’ in the title or abstract and reporting LDL cholesterol data of patients treated with statins were evaluated for inclusion in the study. From the initial search result a total of 1795 papers, 39 manuscripts with 63 study arms were selected for analysis and the data of 3486 patients were included. Descriptive analysis was used to assess the data. Weighted averages of the data were also calculated.

RESULTS
The female/male ratio was 42/58. The mean age was 52.9±10.1 years. The proportion of patients with the recommended LDL cholesterol level of <70 mg/dL after treatment with statins was 15.3%. In all, 10.2% of the patients who were prescribed a low-dose statin and 28.0% of those who were prescribed a high-dose statin had an LDL cholesterol of <70 mg/dL after treatment. Among patients who were being treated with statins for ≤2 months, 25.7% achieved an LDL cholesterol level of <70 mg/dL. Among those who were being treated with statins for 2–4 months and >4 months the proportion was 11.4% and 9.7%, respectively. The percentage of patients at the target level was 21.8%, 21.7%, 17.9%, 8.6%, and 0.8% among those using atorvastatin, simvastatin, rosuvastatin, fluvastatin, and pravastatin, respectively.

CONCLUSION
In Turkey, only 15% of the patients who had received statin therapy had a LDL cholesterol level of <70 mg/dL. Revision of the current treatment should be considered to reach the target levels recommended in the guidelines, especially for patients with high cardiovascular risk.

Keywords: Low-density lipoprotein cholesterol, lipid profile, statin; Turkey.

How to cite this article
Pınar Kızılırmak, Zeki Öngen, Meral Kayıkçıoğlu, Lale Tokgözoğlu. Evaluation of statin use on LDL cholesterol levels in Turkey: A systematic review. Turk Kardiyol Dern Ars. 2020; 48(2): 137-148

Corresponding Author: Pınar Kızılırmak, Türkiye
© Copyright 2020 Archives of the Turkish Society of Cardiology
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