Archives of the Turkish Society of Cardiology
The relationship between interleukin-6 polymorphism and the extent of coronary artery disease in patients with acute coronary syndrome [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2007; 35(5): 278-283

The relationship between interleukin-6 polymorphism and the extent of coronary artery disease in patients with acute coronary syndrome

Fuat Gündoğdu1, Öznur Özdemir1, Serdar Sevimli1, Mahmut Açıkel1, İbrahim Pirim2, Şule Karakelleoğlu1, Şakir Arslan1, Serkan Serdar1
1Department Of Cardiology, Faculty Of Medicine, Ataturk University, Erzurum, Turkey
2Departments Of Medical Biology And Genetics, Faculty Of Medicine, Ataturk University, Erzurum, Turkey


OBJECTIVES
We investigated plasma fibrinogen and interleukin-6 (IL-6) levels and the frequency of IL-6 polymorphism in patients with acute coronary syndrome.

STUDY DESIGN
A case-control study was conducted in 115 patients who underwent coronary angiography for suspected ischemic heart disease. The patients were classified into two groups according to angiography findings: 65 patients (49 males, 16 females; mean age 61±10 years) had less extensive coronary artery disease (CAD) (1-vessel stenosis), and 50 patients (36 males, 14 females; mean age 61±9 years) had extensive CAD (≥2-vessel stenosis). Fasting blood samples were taken to determine serum lipids, high sensitivity C-reactive protein, IL-6, and fibrinogen levels. The genotypic distribution and the IL-6 C/G-174 polymorphism were determined by polymerase chain reaction.

RESULTS
Patients with less extensive CAD had a significantly lower prevalence of positive familial CAD and significantly lower plasma IL-6 and fibrinogen levels compared to those with extensive CAD (p<0.05). IL-6 polymorphism was detected in 20 patients (17.4%), its frequency being significantly higher in patients with extensive CAD (32% vs 6.2%; p<0.001).

CONCLUSION
Our results suggest that the presence of the IL-6 C/G-174 polymorphism and increased IL-6 and fibrinogen levels are strongly associated with the inflammatory system and hemodynamical significance of CAD.

Keywords: Coronary arteriosclerosis, genotype, inflammation mediators; interleukin-6/blood/genetics; polymorphism, genetic; risk factors

How to cite this article
Fuat Gündoğdu, Öznur Özdemir, Serdar Sevimli, Mahmut Açıkel, İbrahim Pirim, Şule Karakelleoğlu, Şakir Arslan, Serkan Serdar. The relationship between interleukin-6 polymorphism and the extent of coronary artery disease in patients with acute coronary syndrome. Turk Kardiyol Dern Ars. 2007; 35(5): 278-283

Corresponding Author: Fuat Gündoğdu, Türkiye
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