ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Uric Acid Is Associated with Worsening of Diastolic Function and Adverse Outcomes in Patients with Coronary Slow Flow [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(1): 3-9 | DOI: 10.5543/tkda.2022.32035

Uric Acid Is Associated with Worsening of Diastolic Function and Adverse Outcomes in Patients with Coronary Slow Flow

Yonghong Niu1, Hongju Zhang2, Xiao Dong Li3, Yutong Cheng4, Su Wang4, Qian Wang4, Chayakrit Krittanawong5, Edward A. El-Am6, Ning Ma2, Tao Sun4
1Department of Cardiology, First Affiliated Hospital of Tsinghua University, Beijing, China
2Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
3Department of Cardiology, Shougang Changzhi Steel Hospital, Shanxi, China
4Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
5Department of Cardiology, Baylor College of Medicine, Houston, Texas, USA
6Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA


OBJECTIVE
The impact of uric acid on worsening of diastolic function and clinical outcomes in patients with coronary slow flow remains unclear. This study aims to investigate possible associations between serum uric acid, worsening of diastolic function, and major adverse cardiovascular events in coronary slow flow patients.


METHODS
Blood samples were obtained prospectively from 537 patients who had been angiographically diagnosed with coronary slow flow. Of those, 425 patients underwent comprehensive cardiac function assessment both before and after maximal treadmill exertion by stress echocardiography. The association between serum uric acid and major adverse cardiovascular events was examined using Cox proportional hazards regression model.


RESULTS
Among the 425 patients (mean age: 58 ± 11 years; 52.2% men), worsening of diastolic function occurred in 176 (41.4%) after exercise stress. Patients with worsening of diastolic function had elevated levels of serum uric acid compared to those without
(5.7 [4.1, 6.7] vs 4.3 [3.6, 5.3] mg/dL, respectively; P <.001). Higher serum uric acid levels were also significantly associated with neutrophil counts and high-sensitive C-reactive protein in patients with worsening of diastolic function but not in those without. Multivariate regression analysis found serum uric acid to be an independent predictor of worsening of diastolic function (odds ratio = 1.87 [1.17-3.82], P =.023). Moreover, serum uric acid remained associated with major adverse cardiovascular events even after adjusting for echocardiographic and clinical variables (hazard ratio = 1.56 [1.03-2.89], P =.016).


CONCLUSION
Serum uric acid is associated with worsening of diastolic function and may be mediated by inflammation. These findings indicate that uric acid is a risk factor for major adverse cardiovascular events in patients with coronary slow flow.

Keywords: Coronary slow fl, ow, major adverse cardiovascular events, uric acid, worsening of diastolic function

How to cite this article
Yonghong Niu, Hongju Zhang, Xiao Dong Li, Yutong Cheng, Su Wang, Qian Wang, Chayakrit Krittanawong, Edward A. El-Am, Ning Ma, Tao Sun. Uric Acid Is Associated with Worsening of Diastolic Function and Adverse Outcomes in Patients with Coronary Slow Flow. Turk Kardiyol Dern Ars. 2023; 51(1): 3-9

Corresponding Author: Tao Sun
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2023 Archives of the Turkish Society of Cardiology