ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Effects of Defibrotide Administration on Restenosis After Successfull PTCA [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1992; 20(3): 179-181

Effects of Defibrotide Administration on Restenosis After Successfull PTCA

Y.Vedat AYTEKİN1, Muzaffer ÖZTÜRK1, Servet ÖZTÜRK1, Orhan ULUTİN1, Cem DEMİROĞLU1

We have investigated the effect of defibrotide (D) administration on restenesis after successfull PTCA. 66 PTCA patients were randomized to D [D (+)]or non-D [D(-)] groups. PTCA was successfull in 27 of 33 patients in d ( +) group in which defibrotide was administered before and after PTCA, and in 30 of 33 in D (-) group who were given only the rootine therapeutic scheme. So we considered the results of 57 patients in whom the PTCA procedure were successfull. Coronary angiographic controls were made after the onset of the symptoms in symptomatic patients, or after 6th month of PTCA in asymptomatic patients. There were no significant differences between D (-) and D ( +) groups according to age, sex, hypertension, diabetes, hypercholesterolemia, smoking, family history of coronary artery disease, the localization of the lesions in left anterior descending artery, circumflex artery and right coronary, artery, the mean stenosis degree of the lesions before PTCA. There were also no significant difference between the mean stenosis degree of the lesions after PTCA in two groups. Angiographic restenosis were found in 9 patients (30 %) and 9 lesions (24.3 %) in D(-) group, and in 15 patients (57.6 %) and 15 lesions (45.4 %) in D (+) group (p: ns). In conclusion defibrotide administraiton does not effect the incidence of restenosis significantly after successfull PTCA.


How to cite this article
Y.Vedat AYTEKİN, Muzaffer ÖZTÜRK, Servet ÖZTÜRK, Orhan ULUTİN, Cem DEMİROĞLU. Effects of Defibrotide Administration on Restenosis After Successfull PTCA. Turk Kardiyol Dern Ars. 1992; 20(3): 179-181
Manuscript Language: Turkish


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