ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Effect of Short-Term Oral Sildenafil Treatment in Primary Pulmonary Hypertension [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2003; 31(2): 82-87

Effect of Short-Term Oral Sildenafil Treatment in Primary Pulmonary Hypertension

Telat KELEŞ1, Sinan AYDOĞDU1, Kadir POLAT3, Tahir DURMAZ4, Deniz ŞAHİN1, Alper CANBAY1, Erdem DİKER1, Koray GÜRSEL1
1
2
3
4
5
6
7
8

Primary pulmonary lıype rlemion ( PPH) isa disease wir/ı a poor prognosis w il h 110 effective treatment. Sildenafil. a se/ecrive phosp/ıodiesterasf!;-5 enzy11ıe inhibilor. awses ptt!monary vasodilatalion by increasing eyetic guanosine monoplıosplı ate /eve/s. In order lo investigcue 1/ıe effecl and safely of slıorl-temı orallı iglı-dose sildenafil treatment on hemodynamic pammeters in patienls wilh PPH. 8 parients were given sildelıafil ata dose of 200 mg/day (50 mg q.i .d) for 3 days. Righr m ıd le.flhearl catlıeterizaıion was performed be.fore lrea/ment and 1 h oıır af/er the lm'f dose of si/denafil. No significant change in mean systemic arterial blood pressııre (90±9 mmHg. pre-treatmetl/; 88±7 mmHg. post-lreatment; p=0./25) was obserl'ed wilh a sigtıificant decrease inmeatı pulmonary artery pressure (60±1/mmHg. pre-treaunellf; 54±14mmHg. post-tremment; p=0.008). No s ide effect reqııiring withdrawa/ oj si/denafil was observed. Wlıen palients were eva/uated indiviclııally. tlıe decrease inmean pulmonary artery pressure ıvas over 20% in 2 patients. benveen 5 and /0% in 2 patiellfs and belo ıv 5% in 4 patienls. Thus. sildena.fil treatmeni decreased meatı pu/monary artery pressure by a selective vasodilatory effect on pttlmonary vascu/ar bed in patients ıvitlı PPH. Nonetheless. this effect is variable among patients.

Keywords: sildenafil, primary pulmonary lypertension. pulmonary vasoldilatation

How to cite this article
Telat KELEŞ, Sinan AYDOĞDU, Kadir POLAT, Tahir DURMAZ, Deniz ŞAHİN, Alper CANBAY, Erdem DİKER, Koray GÜRSEL. Effect of Short-Term Oral Sildenafil Treatment in Primary Pulmonary Hypertension. Turk Kardiyol Dern Ars. 2003; 31(2): 82-87
Manuscript Language: Turkish


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 Archives of the Turkish Society of Cardiology



Kare Publishing is a subsidiary of Kare Media.