ISSN 1016-5169 | E-ISSN 1308-4488
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The Effects of Vitamin D on Myocardial Function Demonstrated by Speckle-Tracking Echocardiography in Children with Beta Thalassemia [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(5): 328-332 | DOI: 10.5543/tkda.2023.85265

The Effects of Vitamin D on Myocardial Function Demonstrated by Speckle-Tracking Echocardiography in Children with Beta Thalassemia

Ayça Koca Yozgat1, Emine Azak2, Dilek Kaçar1, Melek Işık1, Özlem Arman Bilir1, Zeliha Güzelküçük1, İbrahim İlker Çetin3, Namık Yaşar Özbek1, Neşe Yaralı4
1Department of Pediatric Hematology-Oncology, Ankara Health Sciences University, Ankara City Hospital, Ankara, Türkiye
2Department of Pediatric Cardiology, Ankara Health Sciences University, Ankara City Hospital, Ankara, Türkiye
3Department of Pediatric Cardiology, Yıldırım Beyazıt University, Ankara City Hospital, Ankara, Türkiye
4Department of Pediatric Hematology-Oncology, Yıldırım Beyazıt University, Ankara City Hospital, Ankara,Türkiye


OBJECTIVE
Beta thalassemia major is an inherited hemoglobin disorder resulting in chronic hemolytic anemia. Cardiac involvement is the main cause of death in patients. Speckle-tracking echocardiography is a feasible method for the evaluation of cardiac function via an assessment of the longitudinal deformation of the myocardium through the cardiac cycle. The aim of our study is to evaluate the association between vitamin D deficiency and deformation of the left ventricular myocardium measured by speckle-tracking echocardiography in children with thalassemia major.


METHODS
In this prospective study, 33 thalassemic patients with vitamin D deficiency were enrolled. Cardiac magnetic resonance T2* value, conventional echocardiography, and speckle tracking, and also left ventricular longitudinal and circumferential strain values were measured. Myocardial functions of the patients with vitamin D deficiency or insufficiency were evaluated by speckle-tracking echocardiography before and after vitamin D replacement.


RESULTS
The mean age of the patients was 15.4 ± 3.09 years. Vitamin D level was deficient in 30 (90%) and insufficient in 3 (10%) of them. Speckle-tracking analysis showed a significantly decreased absolute value of the left ventricular global longitudinal strain before vitamin D replacement. A significant improvement in the global longitudinal strain was detected after vitamin D replacement (P < 0.05). A statistically significant increase was observed in parameters showing left ventricular systolic and diastolic functions after vitamin D replacement.


CONCLUSION
Vitamin D deficiency is frequently observed and causes decreased contractility in thalassemic patients. In our study, we observed that our patients’ cardiac functions had improved after vitamin D replacement therapy.

Keywords: Cardiac function, thalassemia major, vitamin D

How to cite this article
Ayça Koca Yozgat, Emine Azak, Dilek Kaçar, Melek Işık, Özlem Arman Bilir, Zeliha Güzelküçük, İbrahim İlker Çetin, Namık Yaşar Özbek, Neşe Yaralı. The Effects of Vitamin D on Myocardial Function Demonstrated by Speckle-Tracking Echocardiography in Children with Beta Thalassemia. Turk Kardiyol Dern Ars. 2023; 51(5): 328-332

Corresponding Author: Ayça Koca Yozgat, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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