The Value of the Combination of Two Different Calcium Antagonists in the Treatment of Hypertension

40 patients with moderate hypertension were divided into two groups. 20 patients (A group) used 240 mg Verapamil and another 20 patients (B group) used 20 mg Nitrendipine during the first six weeks. Then 10 mg Nitrendipine plus 120 mg Verapamil were given to these 40 patients during the second six weeks. After the combination therapy 240 mg Verapamil to B group and 20 mg Nitrendipine to A group were given during the third six weeks. When Verapamil and Nitrendipine were used alone, blood pressure decreased significantly in each group. However, blood pressure decreased more when the combination therapy was used and increased when the treatment was changed to single drug therapy from two drugs combination. On the other hand side effects were three times less during the combination therapy. It is concluded that the combination of two different calcium antagonists in the treatment of hypertension will be a new dimension in the therapy.