Turk Kardiyol Dern Ars. 2019; 47(7): 554-563 | DOI: 10.5543/tkda.2019.78379
Peripheral polyneuropathy in patients receiving long-term statin therapy
Ibrahim Halil Özdemir1
, Özge Copkiran2
, Hakan Tıkız3
, Canan Tıkız41
Department of Cardiology, Nizip State Hospital, Gaziantep, Turkey2
Department of Cardiology, Menemen State Hospital, İzmir, Turkey3
Department of Cardiology, Celal Bayar University Faculty of Medicine, Manisa, Turkey4
Departmant of Physical Therapy and Rehabilitation, Celal Bayar University Faculty of Medicine, Manisa, Turkey
OBJECTIVE Peripheral neuropathy is an important potential side effect of statin use. This study was an investigation of the incidence of peripheral neuropathy in patients taking atorvastatin or rosuvastatin for hypercholesterolemia and the relationship to the dose and duration of the treatment.
METHODS In all, 50 patients using a statin treatment and 50 healthy controls matched for age and gender who had never taken a statin were included in the study. Polyneuropathy was assessed with a neurological examination and electroneuromyography (ENMG).
RESULTS While no polyneuropathy was detected in the control group, polyneuropathy was seen in 33 (66%) of the patients in the statin group (p<0.01). There was no significant difference between the 2 statin groups in the results of the neurological examination or the ENMG findings regarding the incidence of polyneuropathy (p=0.288 and p=0.720, respectively). Neuropathy was observed in a neurological examination performed within the first year in 50% of the rosuvastatin users and 18% of those taking atorvastatin. The severity of the polyneuropathy increased with the duration of the treatment in the atorvastatin group (p=0.030).
CONCLUSION This study revealed an increased risk of peripheral neuropathy with long-term statin use (>1 year). Electrodiagnostic changes have been detected in motor and sensory nerves in nerve conduction studies of patients on long-term statin treatment. The assessment of neurological symptoms, like tingling, numbness, pain and tremor in the hands and feet, and unsteadiness during walking associated with peripheral neuropathy may be useful in the follow-up of the patients on long-term statin treatment. Early detection of peripheral neuropathy and changing hypercholesterolemia treatment may prevent permanent nerve damage.
Atorvastatin, peripheral neuropathy, rosuvastatin; statin.
How to cite this article
Ibrahim Halil Özdemir, Özge Copkiran, Hakan Tıkız, Canan Tıkız. Peripheral polyneuropathy in patients receiving long-term statin therapy. Turk Kardiyol Dern Ars. 2019; 47(7): 554-563
Corresponding Author: Ibrahim Halil Özdemir, Türkiye