ISSN 1016-5169 | E-ISSN 1308-4488
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The Relationship Between Hypothyroidism and Cardiac Findings in Children With and Without Down Syndrome [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(3): 163-167 | DOI: 10.5543/tkda.2023.70337

The Relationship Between Hypothyroidism and Cardiac Findings in Children With and Without Down Syndrome

Büşra Süzen Celbek1, Hazım Alper Gürsu2, Emine Azak3, Eda Mengen4, Pınar Kocaay5, İbrahim İlker Çetin6
1Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, Ankara, Türkiye
2Department of Pediatric Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Türkiye
3Department of Pediatric Cardiology, Ankara City Hospital, Ankara, Türkiye
4Department of Pediatric Endocrinology, Ankara Training and Research Hospital, Ankara, Türkiye
5Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Türkiye
6Department of Pediatric Cardiology, Yıldırım Beyazıt University, Ankara City Hospital, Ankara, Türkiye


OBJECTIVE
Down syndrome is a genetic syndrome characterized with various dysmorphisms and congenital malformations such as congenital heart diseases. We aimed to evaluate the relationship between Down syndrome, hypothyroidism, and cardiac findings.


METHODS
Thyroid hormone profiles and echocardiographic findings were evaluated. Patients with hypothyroidism and Down syndrome were named group 1; patients with hypothyroidism without Down syndrome group 2 and group 3 was control. The echocardiographic parameters (interventricular septum and left ventricular systolic, diastolic posterior wall thickness, left ventricular end-diastolic diameter, ejection fraction) were indexed to body surface area. Left ventricular mass index and relative wall thickness were calculated. Patients with relative wall thickness equal to or below 0.42 were classified as eccentric hypertrophy or normal geometry, while those over 0.42 as concentric remodeling or concentric hypertrophy.


RESULTS
Thyroid stimulating hormone values of groups 1 and 2 were significantly higher than those of group 3. There were no significant differences for fT4 between the groups. Interventricular septum and left ventricular posterior wall end-diastolic and end-systolic thickness were significantly higher in group 1 than groups 2 and 3. There was no statistically significant difference in left ventricular mass index between groups 1 and 2. In terms of relative wall thickness, 16 out of 29 patients in group 1 were revealed as concentric remodeling, 12 as normal geometry, 1 patient as eccentric hypertrophy. In group 2, 6 patients were revealed as concentric remodeling, 14 as normal geometry. There was no statistically significant difference of left ventricular end-diastolic thickness between 3 groups.


CONCLUSION
Cardiac morphology and functions were significantly affected by hypothyroidism in patients with Down syndrome. Hypertrophy in Down syndrome may be caused by the cellular changes in myocardium.

Keywords: Cardiac function, cellular and molecular cardiology, echocardiography, genetics

How to cite this article
Büşra Süzen Celbek, Hazım Alper Gürsu, Emine Azak, Eda Mengen, Pınar Kocaay, İbrahim İlker Çetin. The Relationship Between Hypothyroidism and Cardiac Findings in Children With and Without Down Syndrome. Turk Kardiyol Dern Ars. 2023; 51(3): 163-167

Corresponding Author: Hazım Alper Gürsu, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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