ISSN 1016-5169 | E-ISSN 1308-4488
pdf
Association of the Single Nucleotide Polymorphisms in the Renin-Angiotensin-Aldosterone System with Hypertension in the Uzbek Population [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2024; 52(3): 182-188 | DOI: 10.5543/tkda.2023.67866

Association of the Single Nucleotide Polymorphisms in the Renin-Angiotensin-Aldosterone System with Hypertension in the Uzbek Population

Darya Zakirova1, Guzal Abdullaeva2, Zaringiz Mashkurova2, Sevara Bekmetova2, Elina Aguryanova1, Fozilakhon Omonova1, Alisher Abdullaev1
1Center for Advanced Technologies, Tashkent, Uzbekistan
2Republican Specialized Research and Practical Medical Center for Cardiology, Tashkent, Uzbekistan


OBJECTIVE
This research aims to identify the association between the nine polymorphic variants (rs4961, rs699, rs4762, rs5186, rs1403543, rs1799998, rs5443, rs2070744, rs1799983) and the occurrence of hypertension and its clinical manifestations in the Uzbek population.


METHODS
The study included 227 individuals, comprising 179 patients with hypertension and 48 controls. Clinical parameters such as age, weight, blood glucose, triglycerides, total cholesterol, low-density lipoprotein and high-density lipoprotein, blood urea nitrogen, creatinine, pulse wave velocity, left ventricular mass, and microalbuminuria levels were identified. We assessed the distribution of allele frequencies of these polymorphic variants in the Uzbek population to establish their association with cardiovascular diseases and their clinical manifestations.


RESULTS
Genetic analysis of the polymorphic variants demonstrated a significant association of the AGT 521 C>T variant with arterial hypertension [P ≤ 0.01; Odds Ratio (OR) = 2.91]. The NOS3 -786 T>C variant correlated with left ventricular hypertrophy (P ≤ 0.05; OR = 0.35) and increased pulse wave velocity (P ≤ 0.01; OR = 0.21). The correlations of the AGTR2 1675 G>A variant with left ventricular hypertrophy (P ≤ 0.01; OR = 1.59) and increased pulse wave velocity (P ≤ 0.01; OR = 0.33) were identified. The AGT 704 T>C variant showed a significant association with increased pulse wave velocity (P ≤ 0.05; OR = 2.73).


CONCLUSION
Four of the nine studied polymorphic variants were associated with clinical manifestations of hypertension in the Uzbek population. These variants can be used as genetic biomarkers to identify the risks of developing cardiovascular diseases and hypertension in the Uzbek population.

Keywords: Hypertension, single nucleotide polymorphism, pulse wave velocity

How to cite this article
Darya Zakirova, Guzal Abdullaeva, Zaringiz Mashkurova, Sevara Bekmetova, Elina Aguryanova, Fozilakhon Omonova, Alisher Abdullaev. Association of the Single Nucleotide Polymorphisms in the Renin-Angiotensin-Aldosterone System with Hypertension in the Uzbek Population. Turk Kardiyol Dern Ars. 2024; 52(3): 182-188

Corresponding Author: Darya Zakirova
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 Archives of the Turkish Society of Cardiology



Kare Publishing is a subsidiary of Kare Media.