Thymosin beta4 levels after successful primary percutaneous coronary intervention for acute myocardial infarction [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2011; 39(8): 654-660 | DOI: 10.5543/tkda.2011.01751

Thymosin beta4 levels after successful primary percutaneous coronary intervention for acute myocardial infarction

Asuman Biçer Yeşilay1, Özlem Karakurt2, Ramazan Akdemir3, Gönül Erden4, Harun Kılıç3, Sadık Açıkel3, Betül Karasu3, Münevver Sarı3, Mustafa Balcı3, Murat Aksoy3
1Department of Cardiology, Harran University School of Medicine, Sanliurfa, Turkey
2Department of Cardiology, Balıkesir Government Hospital, Balıkesir, Turkey
3Department of Cardiology, Ministry of Health Diskapi Yildirim Beyazit Training And Research Hospital, Ankara, Turkey
4Department of Biochemistry, Numune Training And Research Hospital, Ankara, Turkey


OBJECTIVES
Thymosin beta4 (Tβ4) has been shown to have an important role in healing of damaged tissues and promoting cardiomyocyte survival in acute coronary syndromes. We evaluated endogenous Tβ4 levels in patients presenting with ST-elevation acute myocardial infarction (STEMI) before and after successful primary percutaneous coronary intervention (PCI).

STUDY DESIGN
The study included 24 consecutive patients (7 females, 17 males; mean age 55.0±10.9 years) who underwent successful primary PCI for STEMI and 24 age- and sex-matched healthy controls (13 females, 11 males; mean age 57.5±11.7 years) with angiographically normal coronary arteries. To determine Tβ4 levels, blood samples were obtained from STEMI patients on admission and 48 hours after successful PCI, and from controls immediately after coronary angiography.

RESULTS
Compared to controls, baseline levels of high-density lipoprotein cholesterol (46.2±8.9 vs. 34.2±7.2 mg/dl, p<0.001) and Tβ4 (2.9±1.5 vs. 1.5±1.0 µg/ml, p<0.001) were significantly lower, and white blood cell counts (7.6±2.2 vs. 11.4±3.0 103/μl, p<0.001) were significantly higher in the STEMI group. After 48 hours of PCI, the mean Tβ4 level increased significantly to 2.3±0.8 µg/ml (p<0.001) and became similar to that of the control group (p=0.068). There was a significant negative correlation between serum Tβ4 and white blood cell count (r=-0.347, p=0.016).

CONCLUSION
Considering the significant increase in serum Tβ4 levels following successful primary PCI in patients with STEMI, Tβ4 may prove to be a new marker in the assessment of reperfusion success in addition to those used currently.

Keywords: Angioplasty, balloon, coronary, coronary angiography; ischemia; myocardial infarction; reperfusion; thymosin

How to cite this article
Asuman Biçer Yeşilay, Özlem Karakurt, Ramazan Akdemir, Gönül Erden, Harun Kılıç, Sadık Açıkel, Betül Karasu, Münevver Sarı, Mustafa Balcı, Murat Aksoy. Thymosin beta4 levels after successful primary percutaneous coronary intervention for acute myocardial infarction. Turk Kardiyol Dern Ars. 2011; 39(8): 654-660

Corresponding Author: Özlem Karakurt, Türkiye
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