ISSN 1016-5169 | E-ISSN 1308-4488
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Baseline Characteristics and Clinical Insights from the ARTEMIS Registry: A Comprehensive Study of Peripartum Cardiomyopathy in Türkiye [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2024; 52(7): 474-483 | DOI: 10.5543/tkda.2024.63367

Baseline Characteristics and Clinical Insights from the ARTEMIS Registry: A Comprehensive Study of Peripartum Cardiomyopathy in Türkiye

Meral Kayıkçıoğlu1, Murat Biteker2, Ferit Onur Mutluer3, Tuncay Güzel4, Emre Yılmaz5, Emre Demir1, Sanem Nalbantgil1, Faruk Ertaş6, Dilek Çiçek Yılmaz7, Ahmet Temizhan8, Lütfü Aşkın9, Lale Dinç Asarcıklı10, Murat Akçay11, Recep Demirbağ12, Sedat Köroğlu13, Ender Örnek8, Ahmet Çelik7, Mehmet Ata Akıl6, Bayram Arslan14, Lale Tokgözoğlu15, Artemis Investigators*16
1Department of Cardiology, Ege University Faculty of Medicine, Izmir, Türkiye
2Department of Cardiology, Muğlu University Faculty of Medicine, Muğla, Türkiye
3Department of Cardiology, Yeditepe University Hospital, İstanbul, Türkiye
4Department of Cardiology, Health Science University, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Türkiye
5Department of Cardiology, Giresun University Faculty of Medicine, Giresun, Türkiye
6Department of Cardiology, Dicle University, Diyarbakır, Türkiye
7Department of Cardiology, Mersin University Faculty of Medicine, Mersin, Türkiye
8Department of Cardiology, Ankara City Hospital, University of Health Sciences, Ankara, Türkiye
9Department of Cardiology, Gaziantep Islamic Science and Technology University, Gaziantep, Türkiye
10Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Research and Training Hospital, İstanbul, Türkiye
11Department of Cardiology, Ondokuz Mayis University Faculty of Medicine, Samsun, Türkiye
12Department of Cardiology, Harran University, Şanlıurfa, Türkiye
13Department of Cardiology, Afşin State Hospital, Kahramanmaraş, Türkiye
14Department of Cardiology, Ergani State Hospital, Diyarbakır, Türkiye
15Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Türkiye
16*Artemis Investigators: Meral Kayıkçıoğlu, Murat Biteker, Ferit Onur Mutluer, Tuncay Guzel, Emre Yılmaz, Emre Demir, Sanem Nalbantgil, Faruk Ertaş, Dilek Çiçek Yılmaz, Ahmet Temizhan, Lütfü Aşkın, Lale Dinç Asarcıklı, Murat Akçay, Recep Demirbağ, Sedat Köroğlu, Ender Örnek, Ahmet Çelik, Mehmet Ata Akıl, Bayram Arslan, Lale Tokgözoğlu, Ümit Yaşar Sinan, Mustafa Gökhan Vural, Savaş Özer, Cemal Köseoğlu, Murat Sünbül, Yüksel Çavuşoğlu, İbrahim Etem Dural, Ayşe Hoşoğlu, Uğur Önsel Türk, Lütfü Bekar, Servet Altay, Burçak Kılıçkıran Avcı, Ahmet Huyut, Hakan Akıllı, Muhammet Uyanık, Yusuf Ziya Şener, Mahmut Uluganyan, Emre Durakoğlugil, Gülsüm Meral Yılmaz, Veysel Tosun, Mehmet Birhan Yılmaz, Aykut Demirkıran, Sibel Çatırlı Enar, Ömer Faruk Çırakoğlu, Abdülmecit Afşin, Ahmet Karakurt, Zafer Yalım, İbrahim Oğuz, Mehmet Şahin Adıyaman, Mustafa Kaplangöray, Abdi Sağcan, Kenan Toprak, Alper Karakuş, Hasan Korkmaz, Barış Okçun, Bahar Pırat, Turgut Uygun, Mustafa Begenç Taşcanov


OBJECTIVE
Peripartum Cardiomyopathy (PPCM) is a life-threatening, rare disorder that occurs during the late stages of pregnancy or the early postpartum period. The ARTEMIS (A RegisTry of pEripartuM cardIomyopathy in Turkish patientS) aims to investigate the clinical characteristics and outcomes of PPCM in Türkiye, providing insights into its management within this specific population.


METHODS
The ARTEMIS registry retrospectively enrolled patients diagnosed with PPCM within the last five years at 44 cardiology centers across Türkiye. Eligible participants were women over 18 years old, diagnosed with PPCM and without other known cardiac pathology. Data collected included demographic information, clinical presentation, diagnostic modalities, treatment regimens, and outcomes.


RESULTS
The study included 293 patients, predominantly between 25 and 35 years old. The majority presented with symptoms such as dyspnea and palpitations, diagnosed postpartum via echocardiography. A low use of advanced diagnostic imaging was noted, relying primarily on echocardiography for evaluation. Common treatments included beta blockers (97.8%), angiotensin-converting enzyme (ACE) inhibitors (71.3%), and in severe cases, bromocriptine (6.9%). The study highlighted a mortality rate of 5.1%, with surviving patients often requiring continued management for heart failure. Diagnostic challenges and variations in treatment responses were noted, reflecting the complexity of PPCM diagnosis and care.


CONCLUSION
The ARTEMIS registry provides valuable insights into the management of PPCM in Türkiye, highlighting the need for targeted educational programs for healthcare providers and patients. It also underscores the importance of national registries in understanding and improving outcomes for rare diseases like PPCM.

Keywords: B-type natriuretic peptide, cardiomyopathy, dilated cardiomyopathy, echocardiography, heart failure, pregnancy, Turkiye

Corresponding Author: Meral Kayıkçıoğlu
Manuscript Language: English
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