The relationship between galectin-3 and SYNTAX Score I in patients with non-ST-segment elevation myocardial infarction [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2020; 48(8): 723-730 | DOI: 10.5543/tkda.2020.61987

The relationship between galectin-3 and SYNTAX Score I in patients with non-ST-segment elevation myocardial infarction

Alaa Quisi1, Gökhan Alıcı2, Ömer Genç3, Hazar Harbalıoğlu4, İbrahim Halil Kurt3
1Department of Cardiology, Medline Hospital, Adana, Turkey
2Department of Cardiology, Okmeydanı Training and Research Hospital, İstanbul, Turkey;
3Department of Cardiology, Adana City Training and Research Hospital, Adana, Turk
4Department of Cardiology, Düzce Atatürk State Hospital, Düzce, Turkey


OBJECTIVE
The expression of galectin-3 has been found to be increased in human atherosclerotic lesions, suggesting a role in atherogenesis. However, there is a lack of data regarding an association between galectin-3 and the extent, severity, and complexity of coronary artery disease (CAD). The aim of this study was to investigate the relationship between galectin-3 and SYNTAX Score I in patients with non-ST-segment elevation myocardial infarction (NSTEMI).


METHODS
This study included a total of 95 consecutive patients who were diagnosed with NSTEMI and underwent coronary angiography. The baseline galectin-3 level of each patient was measured. The SYNTAX Score I of each patient was calculated using the online calculator (www.syntaxscore.com). The study population was divided into 2 groups: SYNTAX Score I ≤22 group (n=55) and SYNTAX Score I >22 group (n=40).


RESULTS
The galectin-3 level was significantly higher in the SYNTAX Score I >22 group than in the SYNTAX Score I ≤22 group (22.1±8.3 ng/mL vs. 13.5±7.7 ng/mL; p<0.001). Forward stepwise logistic regression analysis demonstrated that galectin-3 (odds ratio [OR]: 1.195, 95% confidence interval [CI]: 1.097–1.302; p<0.001), left ventricular ejection fraction (OR: 0.941, 95% CI: 0.888–0.997; p=0.040), and platelet
count (OR: 1.013, 95% CI: 1.003–1.024; p=0.014) were independently associated with intermediate and high SYNTAX scores. ROC analysis provided a cut-off value of 14.0 ng/mL for galectin-3 to predict an intermediate or high SYNTAX Score I with 75.0% sensitivity and 51.0% specificity (p<0.001).


CONCLUSION
In patients with NSTEMI, galectin-3 was associated
with the extent, severity, and complexity of CAD as
assessed by the SYNTAX Score I.

Keywords: Atherosclerosis, galectin-3; myocardial infarction; SYNTAX score.

How to cite this article
Alaa Quisi, Gökhan Alıcı, Ömer Genç, Hazar Harbalıoğlu, İbrahim Halil Kurt. The relationship between galectin-3 and SYNTAX Score I in patients with non-ST-segment elevation myocardial infarction. Turk Kardiyol Dern Ars. 2020; 48(8): 723-730

Corresponding Author: Alaa Quisi, Türkiye
© Copyright 2021 Archives of the Turkish Society of Cardiology
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