ISSN 1016-5169 | E-ISSN 1308-4488
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Instantaneous Wave-Free Ratio: Novel Adenosine-Free Method to Assess Intracoronary Physiology [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(1): 56-62 | DOI: 10.5543/tkda.2022.57183

Instantaneous Wave-Free Ratio: Novel Adenosine-Free Method to Assess Intracoronary Physiology

Murat Çimci1, Sophie Degrauwe2, Marco Roffi2, Yazan Musayeb2, Bilgehan Karadağ3, Juan F. Iglesias2
1Department of Cardiology, Erbaa State Hospital, Tokat, Türkiye
2Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland
3Department of Cardiology, Istanbul University, Cerrahpasa School of Medicine, Istanbul, Türkiye

Fractional flow reserve assessment was accepted as a crucial strategy in stable patients undergoing coronary angiography without prior noninvasive evaluation in the presence of borderline lesions and in patients with multivessel coronary artery disease. Instantaneous wave-free ratio, measured during a specific diastolic interval, emerged as a nonhyperemic pressure ratio. Due to its advantages such as not requiring a vasodilating agent, rapidity of procedure, pullback phenomena for the assessment of individual stenosis in tandem lesions or diffusely infiltrated vessels, and virtual percutaneous coronary intervention which allows the assessment and justification ‘of‘ optimal coronary revascularization, instantaneous wave-free ratio became a valuable option in the field of coronary physiology. This review aims to address coronary physiological concept with fractional flow reserve and emergence of instantaneous wave-free ratio through cornerstone studies as well as the use of instantaneous wave-free ratio in different clinical scenarios.

Keywords: Interventional cardiology, myocardial ischemia, myocardial revascularization, percutaneous coronary intervention

How to cite this article
Murat Çimci, Sophie Degrauwe, Marco Roffi, Yazan Musayeb, Bilgehan Karadağ, Juan F. Iglesias. Instantaneous Wave-Free Ratio: Novel Adenosine-Free Method to Assess Intracoronary Physiology. Turk Kardiyol Dern Ars. 2023; 51(1): 56-62

Corresponding Author: Murat Çimci, Türkiye
Manuscript Language: English


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