Assessment of the Cohort of the Turkish Risk Factor Study with Framingham Risk Function: an Additional Indicator of the High Absolute Coronary Risk Among Turks [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2001; 29(4): 208-214

Assessment of the Cohort of the Turkish Risk Factor Study with Framingham Risk Function: an Additional Indicator of the High Absolute Coronary Risk Among Turks

Altan ONAT1, Ömer UYSAL1, Gülay HERGENÇ1

This study aimed at comparing the observed coronary risk of the original cohort of the Turkish Adult Risk Factor Study with that predicted by the Framingham risk function. For this purpose, after exclusion of cases of coronary heart disease (CHD), 1479 apparently healthy participants of the cohort aged 30-74 years at baseline formed the study population who were followed up prospectively for 10 years. The predicted risk was contrasted with the observed 67 coronary deaths and ı 09 instances of newly developed CHD. Each partic ipant was given points for each risk factor comprised in the Framingham risk score which is devised for predicting fatal and nonfatal heart attacks and angina. Individual risk percentage was computed from the sum of points. According to the risk function, total fatal or nonfatal CHD was predicted in 1 1 O subjects whereas fatal or nonfatal CHD w as considered to have developed in 97 men and 79 women in the course of the ı O years. Thus, compared to that anticipated by the risk model, an excess of coronary events was observed by 60% in the total cohort (by 40% in men, and 93% in women). When 5 categories of almost equa l s izes were formed based on the Framingham ri sk score, the 1 Oyear ineidence of composite coronary events were virtually identical to that expected from the Framingham risk model in the two low-risk categories in both genders. However, in those with moderate and high ri sk, much more events had developed than predicted. The observed excess coronary events in categories with elevated risk was attributed to excess of the absol ute risk among Turks compared to Western populations which is not incorporated in the Framingham model, rather than to limitations related to our diagnostic methods. We hy poth es ized that the low-grade c hron ic inflammation mediated by the metabolic syndrome plays a greater role in the atherothrombotic process in Turkish adults than in many other populations and that this element raises our absolute coronary risk.

Keywords: Coronary heart disease risk, risk factors, Turkish population

How to cite this article
Altan ONAT, Ömer UYSAL, Gülay HERGENÇ. Assessment of the Cohort of the Turkish Risk Factor Study with Framingham Risk Function: an Additional Indicator of the High Absolute Coronary Risk Among Turks. Turk Kardiyol Dern Ars. 2001; 29(4): 208-214
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