Evaluation of QTc Interval, Tp-e Interval, Tp-e/QT Ratio and Tp-e/QTc Ratio in Patients with Autosomal Dominant Polycystic Kidney Disease

OBJECTIVE
Autosomal dominant polycystic kidney disease (ADPKD) is a complex, progressive condition that primarily involves the kidneys but may also affect other systems, particularly the cardiovascular system. It is characterized by the growth of cysts, leading to decreased renal function and finally to chronic kidney disease. While renal symptoms are the primary focus of treatment, cardiovascular complications play a significant role in morbidity and mortality, and there is a paucity of information regarding the risk of arrhythmias in these patients. The evaluation of myocardial repolarization has been conducted through a variety of methodologies, including Tp-e, QTc, and QT interval assessment.An increasing amount of data suggests that malignant ventricular arrhythmias are linked to a higher Tp-e/QT ratio.

METHOD
This case-control study of 31 adult patients diagnosed with ADPKD was conducted between May 2021 and April 2024. Control group patients were selected using propensity score matching and were considered to minimize confounding factors. All participants underwent electrocardiography and transthoracic echocardiography studies.

RESULTS
Patients with ADPKD had substantially higher QTc intervals, Tp-e intervals, Tp-e/QT ratio, and Tp-e/QTc ratio than the control group (all P=0.001). Correlation analysis revealed significant negative correlations between estimated glomerular filtration rate (ml/min./1.73 m2) and QTc interval (p=0.002), Tp-e interval (p=0.003), Tp-e/QT ratio (p=0.042), and Tp-e/QTc ratio (p=0.021) in patients with ADPKD.

CONCLUSION
Patients with ADPKD were predisposed to sudden cardiac death according to resting ECG findings.