ISSN 1016-5169 | E-ISSN 1308-4488
The relationship between serum parathormone levels and the severity of coronary artery disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2012; 40(7): 589-594 | DOI: 10.5543/tkda.2012.49696

The relationship between serum parathormone levels and the severity of coronary artery disease

Derya Öztürk1, Özlem Özcan Çelebi2, Feridun Vasfi Ulusoy3, Sinan Aydoğdu4
1Department of Cardıology, Gelibolu State Hospital, Çanakkale, Turkey
2Department of Cardıology, Medicana İnternational Hospital, Ankara, Turkey
3Department of Cardıology, Ankara Numune Hospital, Ankara, Turkey
4Department of Cardıology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey

It has been reported that increased parathormone (PTH) levels have unfavorable effects on the cardiovascular system. PTH produces unfavorable effects via either PTH receptors or the renin angiotensin aldosterone system. Data shows that there is a relationship between PTH and coronary artery disease (CAD), although this relationship is still being debated. In this study, we evaluate the relationship between serum PTH levels and CAD.

The study included 260 patients (125 males, 135 females, mean age 56.01±11.9 years) who underwent coronary angiography with a prediagnosis of CAD. Venous blood samples were taken 6 hours before the coronary angiography for the measurement of serum PTH levels. The extent of CAD was evaluated by calculation of Gensini scores.

The Gensini score was 0 in 99 of the patients. Mild atherosclerosis and severe atherosclerosis were determined in 67 and 94 patients, respectively. According to the Gensini score, serum PTH levels were 5.17±2.07 pmol/l, 4.88±2.40 pmol/l and 4.98±3.04 pmol/l, respectively. PTH levels were similar in patients with mild atherosclerosis and with normal coronary arteries (Gensini score 0) (p=0.55). There was no difference in PTH levels between patients with mild and severe atherosclerosis (p=0.77). In addition, no significant difference in PTH levels were detected between those with normal coronary arteries and those with severe atherosclerosis (p=0.78).

Serum PTH level does not determine the extensity of CAD.

Keywords: Coronary artery disease/etiology, parathyroid hormone, vitamin D

How to cite this article
Derya Öztürk, Özlem Özcan Çelebi, Feridun Vasfi Ulusoy, Sinan Aydoğdu. The relationship between serum parathormone levels and the severity of coronary artery disease. Turk Kardiyol Dern Ars. 2012; 40(7): 589-594

Corresponding Author: Derya Öztürk, Türkiye
Manuscript Language: Turkish

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