Turk Kardiyol Dern Ars. 2006; 34(4): 211-217
The clinical and angiographic results of paclitaxel-eluting stents in patients with diabetes mellitus
, İ. Türkay Özcan, Oben Döven, Dilek Çiçek, Ahmet Çamsarı, Eda Tokuçcu, Sabri Seyis, V. Gökhan Cin, M. Necdet Akkuş
Mersin Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı,Mersin
OBJECTIVES We evaluated the long-term results of paclitaxel-eluting stents in diabetic patients with symptomatic coronary artery disease (CAD).
STUDY DESIGN A total of 200 patients with symptomatic CAD, a positive treadmill test, and angiographically confirmed lesions (≥2 mm and ≥70%) underwent paclitaxel-eluting stent implantation (n=267). The patients were assessed in two groups depending on the presence (n=68; 46 men, 22 women; mean age 58.7 years) or absence (n=132; 103 men, 29 women; mean age 56.5 years) of diabetes. Coronary angiographies were repeated after a mean of 12.1±5.1 months following implantation. The mean follow-up was 15.4±6.4 months. Major cardiac events included acute myocardial infarction (AMI), death, and a subsequent intervention.
RESULTS The diabetic group presented with smaller pre-procedure reference vessel diameters, a greater number of bifurcations, long lesions, and long stents (p<0.05). Other quantitative measurements did not differ significantly. Mortality did not occur during the follow-up period. Major cardiac events did not differ significantly between patients with (5.9%) and without (3.8%) diabetes (p>0.05). The incidences of AMI (1.5% vs 0.8%), recurrent angina pectoris (2.9% vs 2.3%), percutaneous angioplasty (2.9% vs 2.3%), and surgical revascularization (1.5% vs 0.8%) were not different in the diabetic and nondiabetic groups, respectively (p>0.05). Major cardiac events were similar in diabetic patients receiving insulin or oral antidiabetic agents.
CONCLUSION Our data favor the effective and safe use of paclitaxel-eluting stents in diabetic patients with respect to comparably low rates of restenosis and major cardiac events.
Coronary angiography; coronary disease; coronary restenosis; diabetes mellitus; paclitaxel/therapeutic use; stents.
How to cite this article
Mustafa Yurtdaş, İ. Türkay Özcan, Oben Döven, Dilek Çiçek, Ahmet Çamsarı, Eda Tokuçcu, Sabri Seyis, V. Gökhan Cin, M. Necdet Akkuş. The clinical and angiographic results of paclitaxel-eluting stents in patients with diabetes mellitus. Turk Kardiyol Dern Ars. 2006; 34(4): 211-217
Corresponding Author: Mustafa Yurtdaş, Türkiye