New Indicator of Cellular Ischemia in Coronary Slow Flow Phenomenon; Cell-Free DNA [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-45605 | DOI: 10.5543/tkda.2020.45605

New Indicator of Cellular Ischemia in Coronary Slow Flow Phenomenon; Cell-Free DNA

mustafa yolcu1, Ali Dogan1, nuri kurtoglu1, veysel sabri hancer2, MEHMET GÜRBÜZEL3
1Department of Cardiology, Yeni Yuzyil Universty, Istanbul, Turkey
2Department of Medical Genetics, Istinye University, Istanbul, Turkey
3Department of Medical Biology, Erzincan Universty, Erzincan, Turkey


OBJECTIVE
Coronary slow flow phenomenon (CSFP) is defined as the delayed arrival of coronary blood flow to distal vascular bed at least in one major epicardial coronary artery. Cell-free DNA (cfDNA) is a type of DNA that circulates freely in blood after being released from nucleated cells. The present study aims to demonstrate whether the level increases of the cfDNA in CSFP, which are indicator of ischemia at the cellular level.

METHODS
The study included 46 patients in total, 23 patients with CSFP, 23 with normal coronary angiograms (NCA). cfDNA levels, clinical, biochemical and angiographic features of the groups were compared.

RESULTS
The mean age was 53.8±10.3 years for the CSFP patients and 56.6±9.4 years for the NCA patients. There was no statistically significant difference between the groups in terms of basal clinical characteristics and laboratory data of patients. Plasma cfDNA levels were 5.04±2.37 ng/µl in CSFP patients and 2.28±1.09 ng/µl in the NCA group (p<0.001).

CONCLUSION
Different invasive and noninvasive studies conducted on patients with the CSFP have also shown myocardial ischemia. In our study, we showed that the levels of cfDNA, a marker of cellular ischemia and damage, have increased significantly as a result of ischemia at cellular level caused by microvascular disruption in patients with CSFP.

Keywords: Cell-Free Nucleic Acids, Myocardial ischemia, Coronary slow flow phenom-enon

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Corresponding Author: mustafa yolcu, Türkiye
© Copyright 2020 Archives of the Turkish Society of Cardiology
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