The prevalence of aspirin resistance in patients with metabolic syndrome [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2009; 37(7): 461-466

The prevalence of aspirin resistance in patients with metabolic syndrome

Göksel Çağırcı1, Özcan Özdemir2, Bilal Geyik2, Serkan Çay3, Sezgin Öztürk3, Dursun Aras3, Serkan Topaloğlu3
1Cardiology Departments of Dışkapı Yıldırım Beyazıt Research and Educational Hospital
2Cardiology Departments of Akay Hospital
3Turkiye Yüksek Ihtisas Heart Education and Research Hospital all in Ankara


OBJECTIVES
Aspirin is recommended for primary prevention in patients with metabolic syndrome (MetS). In this study, we evaluated aspirin resistance in MetS patients.

STUDY DESIGN
The study included 32 patients (23 males, 9 females; mean age 60.7±11.4 years) with the diagnosis of MetS, according to the criteria of the International Diabetes Federation. Aspirin resistance was determined by the PFA-100 analysis (Platelet Function Analyzer). The results were compared with a control group of 30 patients (16 males, 14 females; mean age 61.6±7.3 years) without MetS. All the patients were taking aspirin at the time of the PFA-100 analysis.

RESULTS
Overall, 21 patients (33.9%) were aspirin nonresponders. The prevalence of aspirin resistance was 46.9% in the MetS group, and 20% in the control group. The difference between the two groups was statistically significant (p=0.033). Compared to aspirin responders, fasting blood glucose level was higher (102.0±14.6 mg/ dl vs. 95.3±9.9 mg/dl; p=0.036) and waist circumference tended to be greater in nonresponders (97.4±14.1 cm vs. 89.7±15.0 cm; p=0.053). Multivariate logistic regression analysis showed that MetS (OR 0.28, 95% CI 0.09- 0.88; p=0.029), fasting blood glucose (OR 0.95, 95% CI 0.91-0.99; p=0.045), uric acid (OR 0.46, 95% CI 0.28- 0.76; p=0.002), gamma-glutamyl transferase (OR 1.04, 95% CI 1.00-1.08; p=0.043), high-sensitivity C-reactive protein (OR 1.07, 95% CI 1.01-1.12; p=0.015) levels and platelet count (OR 0.99, 95% CI 0.98-0.99; p=0.034) significantly affected aspirin resistance.
CONCLUSION
Our results show that a significant proportion of MetS patients will not benefit from aspirin use due to high aspirin resistance.

Keywords: Aspirin, drug resistance metabolic syndrome X.

How to cite this article
Göksel Çağırcı, Özcan Özdemir, Bilal Geyik, Serkan Çay, Sezgin Öztürk, Dursun Aras, Serkan Topaloğlu. The prevalence of aspirin resistance in patients with metabolic syndrome. Turk Kardiyol Dern Ars. 2009; 37(7): 461-466

Corresponding Author: Serkan Çay, Türkiye
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