Turk Kardiyol Dern Ars. 2006; 34(7): 419-424
Correlations between left ventricle regional systolic and diastolic functions determined by tissue Doppler echocardiography and myocardial perfusion determined by quantitative rest 99mTc MIBI gated SPECT in patients with dilated cardiomyopathy
, Fatma Berk2
, Serkan İşgören2
, Tayfun Şahin1
, Dilek Ural1
, Hakan Demir2
, Ayşen Ağaçdiken1
, Göksel Kahraman1
, Özlem Çelebi1
, Teoman Kılıç1
, Baki Komsuoğlu11
Department of Cardiology, Kocaeli University Faculty of Medicine, Istanbul, Turkey2
Kocaeli University Medical Faculty, Department of Nuclear Medicine, Istanbul, Turkey
OBJECTIVES We investigated correlations between regional rest myocardial perfusion and regional systolic and diastolic myocardial velocities assessed by 99mTc MIBI gated single-photon emission computed tomography (G-SPECT) and tissue Doppler echocardiography, respectively, in dilated cardiomyopathy (DCM).
STUDY DESIGN The study included 32 patients (27 men, 5 women; mean age 63±12 years) with DCM, with NYHA functional capacity II-IV. Twenty-five patients had ischemic, seven patients had nonischemic DCM. G-SPECT and tissue Doppler imaging studies were performed using short axis views of the basal, mid, and apical levels of the left ventricle, which was divided into 16 segments. For each segment, regional 99mTc MIBI uptake and peak systolic (Sm), and early (Em) and late (Am) diastolic velocities were determined.
RESULTS The mean Sm value (p=0.007) was significantly higher and the mean 99mTc MIBI uptake (p<0.001) was significantly lower in ischemic patients. There was a very good correlation between ejection fractions obtained by the two methods in ischemic (r=0.81, p<0.001) and nonischemic (r=0.76, p=0.05) groups. Regional perfusion levels showed weak but significant correlations with Sm, Em, and Em/Am in the ischemic group. When 99mTc MIBI uptake levels of ischemic patients were assessed in four groups (≥75%, 75% to 50%, 50% to 25%, <25%), Sm values of the first two were significantly higher than that of the group with <25% uptake (p=0.007, p=0.002, respectively). Sm, Em, and Em/Am values were not correlated with 99mTc MIBI uptake in the nonischemic group.
CONCLUSION Myocardial flow velocities determined by Doppler echocardiography are correlated with perfusion abnormalities detected by G-SPECT in ischemic DCM.
Echocardiography, Doppler, cardiomyopathy, dilated; myocardial ischemia; myocardial reperfusion; tomography, emission-computed, single-photon; ventricular function, left
How to cite this article
Güliz Kozdağ, Fatma Berk, Serkan İşgören, Tayfun Şahin, Dilek Ural, Hakan Demir, Ayşen Ağaçdiken, Göksel Kahraman, Özlem Çelebi, Teoman Kılıç, Baki Komsuoğlu. Correlations between left ventricle regional systolic and diastolic functions determined by tissue Doppler echocardiography and myocardial perfusion determined by quantitative rest 99mTc MIBI gated SPECT in patients with dilated cardiomyopathy. Turk Kardiyol Dern Ars. 2006; 34(7): 419-424
Corresponding Author: Güliz Kozdağ, Türkiye