Relation between epicardial adipose tissue thickness and blood pressure levels in prehypertension [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(4): 358-364 | DOI: 10.5543/tkda.2014.35477

Relation between epicardial adipose tissue thickness and blood pressure levels in prehypertension

Osman Turak, Fırat Özcan, Uğur Canpolat, Mehmet A Mendi, Fatih Öksüz, Özcan Özeke, Derya Tok, Kumral Çağlı, Dursun Aras, Sinan Aydoğdu
Türkiye Yüksek Ihtisas Education And Research Hospital, Department Of Cardiology, Ankara, Turkey


OBJECTIVES
Increased epicardial adipose tissue (EAT) thickness is a risk factor for cardiovascular diseases. Previous studies have demonstrated that EAT thickness is increased in patients with hypertension compared with normotensive individuals. In the current study, we aimed to evaluate whether echocardiographically measured EAT thickness differs among patients with normotension, prehypertension, hypertension, and the relation between EAT thickness and blood pressure levels in prehypertensives.

STUDY DESIGN
Patients with prehypertension (n=50) and hypertension (n=50) and normotensive healthy subjects (n=50) according to the American Hypertension Guidelines (Joint National Committee 7) were enrolled in the study. All participants underwent transthoracic echocardiographic examination. EAT thickness was measured from the parasternal long-axis view at end-systole.

RESULTS
Compared with normotensives, EAT thickness was significantly increased in subjects with prehypertension and hypertension (4.1±1.1 mm, 5.4±1.3 mm and 6.6±1.5 mm, respectively, p<0.001). After adjustment for confounding factors like age, gender, high-density lipoprotein, waist circumference, and body mass index, EAT thickness in the normotensive, prehypertensive and hypertensive groups was measured as 4.3±1.2 mm, 5.3±1.2 mm and 6.4±1.4 mm, respectively (p=0.001). In the prehypertensive group, multivariable linear regression analysis showed that EAT thickness was positively correlated with both systolic (r=0.305, p=0.001) and diastolic (r=0.297, p=0.001) blood pressures, independent of other risk factors.

CONCLUSION
In addition to hypertensive subjects, echocardiographically measured EAT thickness is increased in prehypertensive patients when compared with normotensive subjects, independent of other factors. Additionally, increased EAT thickness is significantly correlated with systolic and diastolic blood pressure levels in patients with prehypertension.

Keywords: Echocardiography, epicardium; hypertension; blood pressure; body weight; adipose tissue/pathology.

How to cite this article
Osman Turak, Fırat Özcan, Uğur Canpolat, Mehmet A Mendi, Fatih Öksüz, Özcan Özeke, Derya Tok, Kumral Çağlı, Dursun Aras, Sinan Aydoğdu. Relation between epicardial adipose tissue thickness and blood pressure levels in prehypertension. Turk Kardiyol Dern Ars. 2014; 42(4): 358-364

Corresponding Author: Osman Turak, Türkiye
© Copyright 2019 Archives of the Turkish Society of Cardiology
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