ISSN 1016-5169 | E-ISSN 1308-4488
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Evaluation of ventricular functions using tissue Doppler echocardiography in patients with subclinical hypothyroidism [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2011; 39(2): 129-136 | DOI: 10.5543/tkda.2011.01282

Evaluation of ventricular functions using tissue Doppler echocardiography in patients with subclinical hypothyroidism

Fatma Alibaz Öner1, Selen Yurdakul2, Ender Öner3, Mustafa Kemal Arslantaş4, Murat Usta5, Mecdi Ergüney1
1Istanbul Education And Research Hospital, 2. Clinic Of Internal Medicine, Istanbul, Turkey
2Istanbul Florence Nightingale Hospital, Cardiology Division, Istanbul, Turkey
3Istanbul Education And Research Hospital, Coronary Intensive Care Unit, Istanbul, Turkey
4Istanbul Mehmet Akif Ersoy Cardiovascular Surgery Education And Research Hospital, Anesthezia And Reanimation, Istanbul, Turkey
5Istanbul Education and Research Hospital, Clinical Biochemistry, Istanbul, Turkey


OBJECTIVES
We evaluated right (RV) and left (LV) ventricle functions by tissue Doppler imaging (TDI) in patients with subclinical hypothyroidism (SH).

STUDY DESIGN
Twenty-seven patients (24 women, 3 men; mean age 35.4±11.4 years) with newly diagnosed SH and 22 age- and sex-matched healthy subjects (20 women, 2 men; mean age 34.8±8.6 years) were evaluated by standard echocardiography and TDI. The diagnosis of SH was based on increased serum thyrotropin (TSH) level in the presence of normal free T3 and free T4 levels. The following TDI-derived parameters were measured: isovolumic myocardial acceleration (IVA), peak myocardial velocity during isovolumic contraction (IVV), peak systolic velocity during ejection period (S), and diastolic indices including peak early (E’) and late (A’) diastolic velocities, E’/A’ and E/E’ ratios, and myocardial performance index.

RESULTS
Compared to healthy controls, patients with SH had higher LV mitral A velocity (p=0.022), lower E/A ratio (p=0.021), lower E’ velocity (p=0.019), and higher E/E’ ratio (p=0.017), suggesting significant LV diastolic dysfunction. The patient group also had lower IVV (p=0.004) and IVA (p<0.001), and higher isovolumic contraction time (p=0.012), suggesting LV subclinical systolic dysfunction. For RV parameters, decreased E/A ratio (p=0.014) and E’ velocity (p=0.028) and increased isovolumic relaxation time (p=0.003) in SH patients were consistent with RV diastolic dysfunction, whereas parameters of RV systolic function were similar in the two groups. Myocardial performance indices of both ventricles were also significantly higher in the patient group (p<0.05).

CONCLUSION
Our data suggest that SH is associated with biventricular systolic and diastolic dysfunction.

Keywords: Echocardiography, Doppler, hypothyroidism/complications; ventricular dysfunction, left; ventricular dysfunction, right

How to cite this article
Fatma Alibaz Öner, Selen Yurdakul, Ender Öner, Mustafa Kemal Arslantaş, Murat Usta, Mecdi Ergüney. Evaluation of ventricular functions using tissue Doppler echocardiography in patients with subclinical hypothyroidism. Turk Kardiyol Dern Ars. 2011; 39(2): 129-136

Corresponding Author: Fatma Alibaz Öner, Türkiye
Manuscript Language: English


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Journal Citation Indicator: 0.18
CiteScore: 1.1
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SCImago Journal Rank: 0.348

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