Assessment of Insulin Resistance by the Hyperinsulinemic Euglycemic Glucose Clamp Technique in Young Men With Coronary Artery Disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1998; 26(4): 228-233

Assessment of Insulin Resistance by the Hyperinsulinemic Euglycemic Glucose Clamp Technique in Young Men With Coronary Artery Disease

Cemal SAĞ1, Hakan ERDEM2, Hürkan KURŞAKLIOĞLU1, Adnan HAŞİMİ3, Sedat KÖSE1, Mustafa KUTLU2, Fikri KOCABALKAN2, Ertan DEMİRTAŞ1
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Insulin resistance has an important role in the pathogenesis of metabolic disorders such as hyperinsulinemia, glucose intolcrance, obcsity, and dyslipidemia, all established risk factors for coronary artery disease (CAD). In a number of prospective studies, an independent relationship was noted between CAD and hyperinsulinemia and insulin resistance; and has been suggcsted that insulin resistance isa risk factor for CAD. In this study, insulin res istance was studied by the hyperinsulinemic euglysemic glucose c lamp technique in ı6 male patients w ith CAD (Group ı), diagnosed all by coronary angiography and in 16 male healthy controls (Group 2), younger than 35 years. In our study, "M" value was found as a 4.37± 1.1 mg/kg/min in Group 1, and 7 .9± 1.1 mg/kg/min in Group 2. Insulin resistance was found in 7 of 16 in Group 1. w hile Group 2 no insulin resistance w as found, (p<0.05). In the patient group triglyceride, total and LDLcholesterol, insulin and C-peptide levels were statistically higher than controls (p<0.05). W e found that young patients with newly diagnosed CAD, did show insulin resistance, in variance from other studies. As a result, insulin resistance is an important risk factor in premature CAD.

Keywords: Insulin resistance, coronary artery disease

How to cite this article
Cemal SAĞ, Hakan ERDEM, Hürkan KURŞAKLIOĞLU, Adnan HAŞİMİ, Sedat KÖSE, Mustafa KUTLU, Fikri KOCABALKAN, Ertan DEMİRTAŞ. Assessment of Insulin Resistance by the Hyperinsulinemic Euglycemic Glucose Clamp Technique in Young Men With Coronary Artery Disease. Turk Kardiyol Dern Ars. 1998; 26(4): 228-233
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