Neurofibromatosis type 1 and cardiac manifestations [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(8): 714-716 | DOI: 10.5543/tkda.2015.27557

Neurofibromatosis type 1 and cardiac manifestations

Faruk İncecik1, Özlem M Hergüner1, Sevcan Alınç-erdem2, Şakir Altunbaşak1
1Department of Pediatric Neurology, Çukurova University Faculty of Medicine, Balcali Hospital, Adana
2Department of Pediatric Cardiology, Çukurova University Faculty of Medicine, Balcali Hospital, Adana


OBJECTIVE
Cardiac manifestations of neurofibromatosis type 1 (NF1) may include hypertension, congenital heart disease, and hypertrophic cardiomyopathy. The aim of this study was to evaluate cardiac abnormalities in patients with NF1.

METHODS
Sixty-five NF1 patients (mean age: 9±4.48 years) were retrospectively studied. Standard electrocardiography and echocardiography were performed in all patients.

RESULTS
Cardiac abnormalities were found in 11 of the 65 patients (15.3%). Five patients had mitral valve regurgitation, 2 patients had secundum atrial septal defect, 1 patient had pulmonary valvular stenosis, 1 patient had ventricular septal defect, 1 patient had tricuspid valve regurgitation, and 1 patient had aortic valve regurgitation.

CONCLUSION
Cardiac abnormalities have potential long-term hemodynamic consequences that justify an early diagnosis. Thus, for any patient with NF1, a cardiologic assessment is mandatory at the time of diagnosis and with regular follow-up intervals.

Keywords: Cardiac abnormalities, children, neurofibromatosis type 1

How to cite this article
Faruk İncecik, Özlem M Hergüner, Sevcan Alınç-erdem, Şakir Altunbaşak. Neurofibromatosis type 1 and cardiac manifestations. Turk Kardiyol Dern Ars. 2015; 43(8): 714-716

Corresponding Author: Faruk İncecik, Türkiye
© Copyright 2020 Archives of the Turkish Society of Cardiology
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