Antithrombotic Properties of Nitroglycerin in Patients with Coronary Artery Diease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1996; 24(7): 411-415

Antithrombotic Properties of Nitroglycerin in Patients with Coronary Artery Diease

Şule KARAKELLEOĞLU1, Salim Başol TEKİN2, Mahmut AÇIKEL1, Mahmut ŞAHİN1, Zuhal UMUDUM3, Fatih AKÇAY3, Necip ALP1
1
2
3

This study was desingned to test the effects of nitroglycerin on platelet activation and aggregation in 11 patients with unstable angina pectoris and 14 patients with acute myocardial infarction. Intravenous infusion of nitroglycerin was begun at 0.25 ug/kg/min., and was incresed to 1 ug/kg/min. by controlling blood pressure. Blood samples fo determination of platelet aggregation, (ß-TG) and platelet factor-4 (TF-4) before infusion, after 45 minutes and 24 hours. The levels obtained before nitroglycerin infusion were compared with the measurements of 10 healthy persons. These three parameters were high in the patient group (p=0,0001; p=0,0001). Platelet aggregation was reduced to 80.4±7.5% (p=0,0001) and 85.1±4.9% (p=0,0001) from baseline (97.7±3.3%) at 45 minutes and 24 hours, respectively; ß-TG declined from 54±8 IU/ml to 46±8 IU/ml at 45 minutes of infusion (p<0,0001) and to 42±8 IU/ml at 24 hours (p<0,0001); PF-4 decreased from 13.7±3.1 IU/ml to 10.8±2.7 IU/ml (p=0,0001) and to 9.4±2.3 IU/ml (p=0,0001), respectively. These data suggest that therapeutic doses of nitroglycerin can inhibit platelet functions significantly in patients with acute ischemic syndrome. This beneficial effect of nitrovasodilators in acute ischemic syndromes may contribute to the therapeutic value of these agents.


How to cite this article
Şule KARAKELLEOĞLU, Salim Başol TEKİN, Mahmut AÇIKEL, Mahmut ŞAHİN, Zuhal UMUDUM, Fatih AKÇAY, Necip ALP. Antithrombotic Properties of Nitroglycerin in Patients with Coronary Artery Diease. Turk Kardiyol Dern Ars. 1996; 24(7): 411-415
© Copyright 2020 Archives of the Turkish Society of Cardiology
LookUs & Online Makale