Statins in primary and secondary prevention: what should the target LDL cholesterol value be?

Lowering low-density lipoprotein (LDL) cholesterol levels is among the most important issues in combatting with atherosclerotic diseases. Introduction of statins has launched a new era in this field. Trials conducted in the past 20 years have shown the effect of statins on improved survival, with accumulating evidence justifying the need for lowering the limits set for LDL cholesterol levels. In this review, target LDL cholesterol levels pertaining to statin use are discussed in different risk groups in view of relevant randomized controlled trials.