ISSN 1016-5169 | E-ISSN 1308-4488
Neutrophil to lymphocyte ratio predicts poor functional capacity in patients with heart failure [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(7): 612-620 | DOI: 10.5543/tkda.2014.16363

Neutrophil to lymphocyte ratio predicts poor functional capacity in patients with heart failure

Musa Çakıcı1, Mustafa Çetin1, Adnan Dogan2, Muhammed Oylumlu2, Erdal Aktürk1, Mustafa Polat1, Arif Suner1, Sabri Abuş1
1Department of Cardiology, Adiyaman University Faculty of Medicine, Adiyaman
2Department of Cardiology, Dumlipinar University Faculty of Medicine, Adiyaman

We aimed to assess the relationship between neutrophil to lymphocyte ratio (N/L ratio) and functional capacity (FC) of patients with compensated heart failure (CHF).

A total of 94 consecutive CHF patients and age-gender matched 70 subjects with normal echocardiographic examination were enrolled. Peripheral venous blood samples were drawn before echocardiography examination and treadmill test in all study population. The treadmill test based on modified Bruce protocol was used to determine the functional status of CHF patients. Poor FC was defined as <5 metabolic equivalant (MET) in the exercise test. Afterwards, patients with CHF were divided into two groups with respect to the top and bottom 3 of the N/L ratio.

FC (3.2±2.05 MET vs. 6.1±2.04 MET, p<0.001), ejection fraction (%31.5±7.64 vs. %34.8±6.82, p=0.028) were found to be lower and N-terminal pro-brain natriuretic peptide (NT-proBNP) level (3360±2742 pg/dl vs. 1613±1334 pg/dl, p<0.001) pulmonary artery pressure (46.3±11.50 mmHg vs. 41.5±9.45 mmHg, p=0.049), left atrial diameters (4.6±0.52 cm vs. 4.3±0.43 cm, p=0.005), E/Ea ratio (12.2±4.37 vs. 9.2±3.20, p<0.001) were found to be higher in CHF patients with an N/L ratio >3 than with an N/L ratio <3. The N/L ratio, and log- NT-proBNP level were determined to be a predictive factor of poor FC (odds ratio [OR]=3.085, 95% confidence interval [CI] = 1.520-6.260, p=0.002 and OR=1.585, 95% CI=1.201-2.091, p=0.001, respectively). A cut-off point of 2.74 for the N/L ratio had 79.4% sensitivity and 80% specificity in predicting poor FC.

N/L ratio can be used to predict poor FC in patients with CHF.

Keywords: Biological markers, heart failure, lymphocyte count, neutrophils.

How to cite this article
Musa Çakıcı, Mustafa Çetin, Adnan Dogan, Muhammed Oylumlu, Erdal Aktürk, Mustafa Polat, Arif Suner, Sabri Abuş. Neutrophil to lymphocyte ratio predicts poor functional capacity in patients with heart failure. Turk Kardiyol Dern Ars. 2014; 42(7): 612-620

Corresponding Author: Musa Çakıcı, Türkiye
Manuscript Language: English

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