ISSN 1016-5169 | E-ISSN 1308-4488
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Comparison of Patients with Atrial Fibrillation Without Structural Heart Disease and Normal Population In Terms of Urine Catecholamines [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(3): 168-173 | DOI: 10.5543/tkda.2022.16281

Comparison of Patients with Atrial Fibrillation Without Structural Heart Disease and Normal Population In Terms of Urine Catecholamines

Fuat Polat1, Çağlar Koç2
1Department of Cardiology, Şişli Kolan International Hospital, İstanbul, Türkiye
2Department of Cardiology, Şırnak State Hospital, Şırnak, Türkiye


OBJECTIVE
This study aimed to compare the sympathetic nervous system activity of atrial fibrillation patients without structural heart disease and the normal population in terms of urinary metanephrine levels.


METHODS
Our study was conducted with 40 paroxysmal or persistent patients without structural heart disease and CHA2DS2VASc score of 0 or 1 and 40 healthy controls. Laboratory parameters, demographic characteristics, and 24-hour urine metanephrine levels were compared between the 2 groups included in the study.


RESULTS
Metanephrine value in urine was found to be significantly higher in the atrial fibrillation group (atrial fibrillation group 97.50 ± 17.19 µg/day vs. control group 74.27 ± 15.55 µg/day; P < 0.001). The body mass index of the atrial fibrillation group was found to be significantly higher than the control group (atrial fibrillation group 27.26 ± 2.97 kg/m2 vs. control group 24.05 ± 2.24 kg/m2; P < 0.001). In multivariate linear regression analysis, body mass index (beta: 0.266, P =.02) and urinary metanephrine level (beta: 0.522, P = 0.002) were found to be independent risk factors. According to receiver operating characteristic analysis, it was determined that urinary metanephrine value (area under the curve = 0.834, P < 0.001) and body mass index (area under the curve = 0.803, P < 0.001) predicted the development of atrial fibrillation.


CONCLUSION
Our study found that urinary metanephrine levels were higher in patients with atrial fibrillation without structural heart disease than those without atrial fibrillation, and metanephrine values predicted the development of atrial fibrillation.

Keywords: Atrial fi, brillation, urinary catecholamines, sympathetic nervous system

How to cite this article
Fuat Polat, Çağlar Koç. Comparison of Patients with Atrial Fibrillation Without Structural Heart Disease and Normal Population In Terms of Urine Catecholamines. Turk Kardiyol Dern Ars. 2023; 51(3): 168-173

Corresponding Author: Fuat Polat, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
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SCImago Journal Rank: 0.348

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