Turk Kardiyol Dern Ars. Ahead of Print: TKDA-15686 | DOI: 10.5543/tkda.2020.15686
The effects of genetic polymorphisms and Diabetes Mellitus on the development of peripheral arterial disease
, Serap Tutgun Onrat2
, SÜMEYRA ALAN3
, Mustafa Aldemir4
, Alaettin Avsar1
, İsmet DOĞAN5
, Ersel Onrat11
Afyonkarahisar Health Sciences University, Departments Of Cardiology, Afyonkarahisar, Turkey.2
Afyonkarahisar Health Sciences University, Departments of Medical Genetics, Afyonkarahisar, Turkey.3
Afyonkarahisar Health Sciences University, Departments of Internal Medicine, Afyonkarahisar, Turkey.4
Afyonkarahisar Health Sciences University, Departments Of Cardiyovasculer Sugery, Afyonkarahisar, Turkey.5
Afyonkarahisar Health Sciences University, Departments Of Bioistatistic, Afyonkarahisar, Turkey.
BACKGROUND Peripheral arterial disease (PAD) is a condition that is caused by narrowing of limb arteries due to atherosclerosis. In this study, we investigated the effects of DM and genetic background, solely and together in the pathogenesis of PAD.
METHODS In our study we planned to evaluate the effects of Factor V LEIDEN, Factor V H1299R, Prothrombin G20210A, Factor XIII V34L, B-Fibrinogen -455 G>A, PAI-1 4G/5G, HPA1, MTHFR C677T, MTHFR A1298C, ACE I/D, APO B R3500Q, and APO E polymorphisms using a ViennaLab CVD Strip Assay. In our study have four groups: 50 patients with DM and PAD, 50 patients with PAD and without DM, 30 patients with DM and without PAD and 30 controls.
RESULTS The incidence of MTHFR A1298C and PAI 4G/5G homozygous polymorphisms were higher in PAD (+) patients compared with PAD patients compared with PAD (-) patients. In regression analysis, PAI-1 4G/5G gene homozygous polymorphisms was 17.1 times more risky, (-) patients regardless of diabetic status. In diabetic patients, the incidence of PAI 4G/5G homozygous polymorphisms was higher in PAD (+) (p<0,008) 95% CI(2.113-138.660), MTHFR A1298C homozygous polymorphisms was 316.6 times more risky(p<0.001) 95%CI(10.763-9315.342) the possibility with PADs.
CONCLUSIONS MTHFR A1298C and PAI 4G/5G homozygous polymorphisms may be associated with the development of PAD. The PAI 4G/5G homozygous polymorphisms in the presence of DM is a powerful predictor for the development of PAD.
Peripheral arterial disease, DM, PAI-1 4G/5G, MTHFR A1298C, Factor V G1691A, Polymorphism
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Corresponding Author: Zafer Yalım, Türkiye