Carbon Coating Has No Effect on Inflammatory Response to Primary Stent Deployment [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2002; 30(4): 218-222

Carbon Coating Has No Effect on Inflammatory Response to Primary Stent Deployment

Egemen TAYFUN1, Mehmet E.KORKMAZ1, Haldun MÜDERRİSOĞLU1, Aylin YILDIRIR1, Y.Melek ULUÇAM1, Bülent ÖZİN1, Ecz.Münire TURAN2

To investigate the effects of carbon-coating of stents on inflammatory response we serially measured plasma levels of C-reactive protein (CRP), fibrinogen and cytokines (tumor necrosis factor, interleukins 1-b, 6 and 8) in patients with single vessel coronary stenosis with no any inflammatory or infectious disease who underwent primary stent insertion. Forty-six patients with single coronary lesions were included. Blood samples were obtained before and 2, 4, 6, 24 and 48 hours after the procedure. In a randomized order, either an uncoated MAC (AMG® Raesfeld-Erle, Germany) (UC-MAC) or a carbon-coated MAC (CC-MAC) stents was deployed without predilatation at a maximum pressure of 6 atmospheres for a duration of 90 seconds. Of the 46 patients (38 male, 8 female; age 55 ± 9) included. Fourteen had stable, 27 unstable and 5 atypical angina. According to the ACC / AHA classification 35 lesions (76.1%) were type A, 10 (21.7%) type B and 1 (2.2%) were type C. Stents implanted to stenosis of 28 left anterior descending, 12 circumflex and 6 right coronary arteries. Serum interleukin 6 (IL-6) levels increased significantly in both CC-MAC and UC-MAC groups and returned to normal after 24 hours. Plasma fibrinogen, CRP levels and leukocyte counts also increased in both groups (p<0.05). There was no difference between the two groups in regard to IL-6, CRP and fibrinogen increase. The percent increase in IL-6, fibrinogen or CRP levels were not associated with the stent length, stent size or the clinical presentation (all p>0.05). In conclusion stent implantation increases plasma IL- 6, fibrinogen and CRP levels. This unfavorable inflammatory response seems not to be effected by carbon coating.

How to cite this article
Egemen TAYFUN, Mehmet E.KORKMAZ, Haldun MÜDERRİSOĞLU, Aylin YILDIRIR, Y.Melek ULUÇAM, Bülent ÖZİN, Ecz.Münire TURAN. Carbon Coating Has No Effect on Inflammatory Response to Primary Stent Deployment. Turk Kardiyol Dern Ars. 2002; 30(4): 218-222
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