The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2011; 39(6): 463-468 | DOI: 10.5543/tkda.2011.01578

The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels

Nihat Kalay1, Metin Aytekin2, Mehmet G Kaya1, Kerem Ozbek3, Metin Karayakali3, Erkan Sogut4, Fatih Altunkas3, Ahmet Ozturk3, Fatih Koc3
1Erciyes University School of Medicine Department of Cardiology, Kayseri, Turkey
2Cleveland Clinic Foundation, Department of Pathobiology, Cleveland, Ohio, Usa
3Gaziosmanpasa University School of Medicine Department of Cardiology, Tokat/turkey
4Gaziosmanpasa University School of Medicine Department of Biochemistry, Tokat/turkey


OBJECTIVES
The underlying mechanism of slow coronary flow (SCF) has yet to be elucidated. Increased red cell distribution width (RDW) and uric acid level may be indicative of an underlying inflammatory state. We aimed to investigate RDW and serum uric acid levels in patients with normal coronary arteries and SCF without stenosis.

STUDY DESIGN
The study included 46 consecutive patients (25 males, 21 females; mean age 54±11 years) with angiographically normal coronary arteries but having SCF in all three coronary arteries. The control group consisted of 40 patients (18 males, 22 females; mean age 54±9 years) with angiographically normal coronary arteries without SCF. In both groups, RDW and serum uric acid levels were measured and compared.

RESULTS
In the SCF group, TIMI frame counts measured in the left anterior descending coronary artery, left circumflex coronary artery, and right coronary artery were significantly higher compared to the control group (p<0.05). Patients with SCF exhibited significantly higher RDW (13.4±1.6% vs. 12.6±1.2%, p=0.01) and serum uric acid levels (5.3±1.6 mg/dl vs. 4.7±1.3 mg/dl, p=0.01) compared to controls. In logistic regression analysis, uric acid [Exp(B)=1.612, 95% CI 0.206-5.35, p=0.021] and RDW [Exp(B)=1.496, 95% CI 0.403-4.72, p=0.030] were found as independent predictors of SCF.

CONCLUSION
Our findings show that patients with SCF have significantly increased RDW and serum uric acid levels. This may help throw more light on the pathophysiological basis of SCF.

Keywords: Biological markers, blood flow velocity, coronary circulation, erythrocyte indices; inflammation; uric acid

How to cite this article
Nihat Kalay, Metin Aytekin, Mehmet G Kaya, Kerem Ozbek, Metin Karayakali, Erkan Sogut, Fatih Altunkas, Ahmet Ozturk, Fatih Koc. The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels. Turk Kardiyol Dern Ars. 2011; 39(6): 463-468

Corresponding Author: Fatih Koc, Türkiye
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