Turk Kardiyol Dern Ars. 2014; 42(8): 701-709 | DOI: 10.5543/tkda.2014.03272
The association between coronary atherosclerotic burden and asymmetric dimethylarginine, carotis intima media thickness and endothelial function
, Murat Ziyrek1
, Şükran Erdem1
, Murat Civan1
, Uzay Görmüş2
, Sinan Şahin3
, Zeydin Acar3
, Çavlan Çiftçi11
Department of Cardiology, Istanbul Bilim University Faculty of Medicine, Istanbul2
Department of Biochemistry, Istanbul Bilim University Faculty of Medicine, Istanbul3
Department of Cardiology, Trabzon Kanuni Training and Research Hospital, Trabzon
OBJECTIVES Detection of extent and severity of atherosclerosis using easy, non-invasive methods is of great importance. Atherosclerotic burden may be evaluated with the Gensini scoring system (GSS). Carotis intima media thickness (CIMT), plasma asymmetric dimethyl arginine (ADMA) level, and endothelial dysfunction are well known surrogate markers of atherosclerosis. The aim of this study was to evaluate the relationship between atherosclerotic burden determined by the GSS, and ADMA, CIMT and endothelial function.
STUDY DESIGN Consecutive patients who had undergone coronary angiography were evaluated. 50 patients with acute coronary syndrome (ACS), 50 patients with stable coronary artery disease (SCA), and 50 patients with normal coronary arteries (NCA) were included. All subjects GSS, ADMA, CIMT and endothelial functions were evaluated and compared.
RESULTS GSS was higher in ACS than SCA (75.4 vs 54.9; p<0.001). CIMT was higher in ACS and SCA in compared to NCA (0.98, 0.96, 0.78 mm respectively; p<0.001). Endothelium derived vasodilatory response (EDVR) was decreased in ACS and SCA in compared to NCA (3.5±2.1%, 3.3±1.8%, 7.2±3.5% respectively; p<0.001). Plasma ADMA concentration was higher in ACS and SCA in compared to NCA (0.928, 0.992, 0.475 μmol/l respectively; p<0.001). There was a weak positive correlation between GSS and plasma ADMA levels (r=0.293; p=0.002), an intermediate positive correlation between GSS and CIMT (r=0.508; p<0.001), and an intermediate negative correlations between GSS and EDVR (r= -0.662; p<0.001).
CONCLUSION This study showed that CIMT, ADMA concentration and endothelial dysfunction were significantly associated with CAD. However, only the GSS was significantly different between ACS and SCA groups.
Acute coronary syndrome, asymmetric dimethylarginine, carotid intima-media thickness, coronary artery disease; endothelium.
How to cite this article
Fatma Can, Murat Ziyrek, Şükran Erdem, Murat Civan, Uzay Görmüş, Sinan Şahin, Zeydin Acar, Çavlan Çiftçi. The association between coronary atherosclerotic burden and asymmetric dimethylarginine, carotis intima media thickness and endothelial function. Turk Kardiyol Dern Ars. 2014; 42(8): 701-709
Corresponding Author: Murat Ziyrek, Türkiye