ISSN 1016-5169 | E-ISSN 1308-4488
Surrogates of the Left Ventricular Thrombus Resolution: A Retrospective Data Review [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2022; 50(3): 168-174 | DOI: 10.5543/tkda.2022.21068

Surrogates of the Left Ventricular Thrombus Resolution: A Retrospective Data Review

Hosameldin Salah Shabib Ahmed1, Hüseyin Ede1, Ahmed Sobhy Hassan Ghonim Mahfouz2, Alaa Abdullah Ali Rahhal2, Muhammad Abdulhakim Ali2, Ammar Fares Alhaj Issa1, Abdul Baki Jasem Senjar1, Sumaya Mehdar Al Saadi Al Yafei2, Abdul Rahman Mohammad Said Arabi1, Awad Razaq Al-Qahtani1
1Department of Cardiology, Hamad Medical Corporation Heart Hospital, Doha, Qatar
2Department of Pharmacology, Hamad Medical Corporation Heart Hospital, Doha, Qatar

The left ventricular thrombus is one of the serious complications of ischemic cardio- myopathy. In this study, we aimed to search for the independent factors to predict the resolu- tion of left ventricular thrombus.

This retrospective study included all patients with coronary artery disease, aged above 18 years old, and with the thrombus at the apical location of the left ventricle. Demographic, clinical, and echocardiographic characteristics of the patients were recorded. Major adverse cardiovascular events developed within the follow-up period were recorded. The time in the therapeutic range of each patient was calculated. The presence of left ventricular thrombus beyond 180 days despite warfarin usage was classified as persistent left ventricular thrombus.

The study included 174 subjects (169 males and 5 females). The mean age of the study population was 54.5 ± 11.0 years. The number of patients in whom the left ven- tricular thrombus resolved with treatment in less than 180 days was 56 (32.2%). Median anticoagulation time in the study population was 252 [150-480] days and the meantime in the therapeutic range of the patients was 54 ± 19%. The time in therapeutic range value of the groups was similar (P =.593). It was found that concomitant clopidogrel use (P =.003) and left ventricular thrombus area (P <.001) were the independent predictors of left ventricular thrombus resolution within less than 180 days in the logistic regression analysis.

Concomitant use of clopidogrel was found to be associated with left ventricular thrombus resolution but left ventricular thrombus size was related to left ventricular thrombus persistency. Although standard 3-6 months of anticoagulation is advised for left ventricular thrombus, considering the presence of these predictors in such patients may guide the physi- cians to individualize the treatment.

Keywords: Left ventricular thrombus, coronary artery disease, echocardiography, clopidgrel, warfarin

How to cite this article
Hosameldin Salah Shabib Ahmed, Hüseyin Ede, Ahmed Sobhy Hassan Ghonim Mahfouz, Alaa Abdullah Ali Rahhal, Muhammad Abdulhakim Ali, Ammar Fares Alhaj Issa, Abdul Baki Jasem Senjar, Sumaya Mehdar Al Saadi Al Yafei, Abdul Rahman Mohammad Said Arabi, Awad Razaq Al-Qahtani. Surrogates of the Left Ventricular Thrombus Resolution: A Retrospective Data Review. Turk Kardiyol Dern Ars. 2022; 50(3): 168-174

Corresponding Author: Hüseyin Ede
Manuscript Language: English

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