Effect of Adding Diltiazem of Cold Blood Potassium Cardioplegia on Myocardial Protection [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1996; 24(2): 102-106

Effect of Adding Diltiazem of Cold Blood Potassium Cardioplegia on Myocardial Protection

Ahmet BALTALARLI1, Rıza TÜRKÖZ1, B. Hayrettin ŞİRİN1, Levent YILIK1, Cengiz ÖZBEK1, Ayhan AKÇAY1, Banu DENGİZ1, Mansur ŞAĞBAN1

It is still controversial whether the use of calcium channel blackers in cardioplegic solutions decreases ischemic and reperfusion damage. In this study, the effect of diltiazem addition to cold blood potassium cardioplegia in the induction phase on myocardial protection was investigated. A prospective, randomized trial was instituted to evaluate the hemodynamic and myocardial metabolic recovery in 20 patients undergoing elective aortocoronary bypass with either diltiazem in cold blood potassium cardioplegia (diltiazem group, n=lO) or cold blood potassium cardioplegia (control group, n=IO). In the diltiazem group, 150 mg/kg diltiazem was added to the cardioplegic solution in the induction phase of cardioplegia. In all cases, blood samples for measurement of lactate level and cakulation of lactate extraction were taken from coronary sinus and radial artery at the beginning and the 30th minute of reperfusion period. CK-MB levels were measured in the intensive care at postoperative 6th and 18th hours. Tle hemodynamic findings of both diltiazem and control groups were compared in the preoperative and early postoperative periods. Lactate production was significantly lower in the diltiazem group at the beginning of the reperfusion period (p0.05). CK-MB level was significantly higher in the control group in the postoperative period. Similar hemodynanic findings were obtained in both groupsin the preoperative and the early postoperative periods. We concluded that diltiazem addition to cold blood potassium cardioplegia decreases ischemic and reperfusion damage and has a beneficial effect on myocardial protection.


How to cite this article
Ahmet BALTALARLI, Rıza TÜRKÖZ, B. Hayrettin ŞİRİN, Levent YILIK, Cengiz ÖZBEK, Ayhan AKÇAY, Banu DENGİZ, Mansur ŞAĞBAN. Effect of Adding Diltiazem of Cold Blood Potassium Cardioplegia on Myocardial Protection. Turk Kardiyol Dern Ars. 1996; 24(2): 102-106
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