Türk Kardiyoloji Derneği Arşivi
[Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2001; 29(4): 202-207

Effects of Soy Protein Diet on Endothelial Functions and Lipid Parameters

Aylin YILDIRIR1, Lâle TOKGÖZOĞLU1, Tülay ODUNCU1, Aytekin OTO1, İbrahim HAZNEDAROĞLU1, Devrim AKINCI1, Gülden KÖKSAL1, Elif SADE1, Şerafettin KİRAZLI1, Sırrı KES1

Replacement of animal protein in the diet with soy protein is associated with decreased cholesterol levels. However, the effects of soy protein diet on endothelial function are not well known. The aim of the study was to investigate the effects of soy protein diet on plasma lipids and endothelial function parameters assessed by two different methods. Twenty hypercholesterolemic, non-smoker male patients (age 50± I 2) w ith a normal body mass index were inc luded. After calculating their daily requirements, a diet with 25-30% of energy from fats, 1 0-ı 2% from proteins and the rest from carbohydrates was instituted. Sixty percent of the animal source proteins of the diet were substituted by soy. The anthropometric measures, lipid parameters and endothelial functions of the subjects were assessed at baseline and 6 weeks after soy protein diet. Flow mediated endothelium dependent dilatation (EDD) and plasma thrombomodulin (TM) levels were evaluated as endothelial function parameters.
RESULTS
After diet plasma total cholesterol, lowdensity lipoprotein cholesterol, apolipoprotein B and triglyceride levels decreased significantly (pCONCLUSION
Soy protein diet significantly improves plasma lip id profile in patients with hypercholesterolemia. Furthermore, the endothelial function as judged by two different methods (EDD and plasma TM levels) also improve with soy protein diet.

Keywords: Soy protein, hypercholesterolemia, endothelial function, thrombomodulin.

Effects of Soy Protein Diet on Endothelial Functions and Lipid Parameters

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Aylin YILDIRIR, Lâle TOKGÖZOĞLU, Tülay ODUNCU, Aytekin OTO, İbrahim HAZNEDAROĞLU, Devrim AKINCI, Gülden KÖKSAL, Elif SADE, Şerafettin KİRAZLI, Sırrı KES. Effects of Soy Protein Diet on Endothelial Functions and Lipid Parameters. Turk Kardiyol Dern Ars. 2001; 29(4): 202-207
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