ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Lymphocytopenia is associated with poor NYHA functional class in chronic heart failure patients with reduced ejection fraction [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(5): 427-433 | DOI: 10.5543/tkda.2015.89439

Lymphocytopenia is associated with poor NYHA functional class in chronic heart failure patients with reduced ejection fraction

Hasan Yucel1, Meltem Refiker Ege2, Ali Zorlu1, Hakki Kaya1, Osman Beton1, Hasan Gungor3, Gurkan Acar4, Ahmet Temizhan5, Yüksel Çavuşoğlu6, Mehdi Zoghi7, Mehmet Eren8, Dilek Ural9, Mehmet Birhan Yilmaz1
1Cumhuriyet University, Departments of Cardiology, Sivas, Turkey
2Private Sincan Koru Hospital, Departments of Cardiology, Ankara, Turkey
3Adnan Menderes University, Departments of Cardiology, Aydın, Trkey
4Sütçü İmam University, Departments of Cardiology, Kahramanmaraş, Turkey
5Yuksek Ihtisas Hospital, Cardiology Clinics, Ankara, Turkey
6Osmangazi University, Department of Cardiology, Eskişehir, Turkey
7Ege University Department of Cardiology, Izmir, Turkey
8Siyami Ersek Education And Research Hospital, Cardiology Clinics, İstanbul, Turkey
9Kocaeli University, Department of Cardiology, Kocaeli, Turkey


OBJECTIVE
In heart failure (HF) patients, functional capacity has been demonstrated to be a marker of poor prognosis, independent of left ventricular ejection fraction (EF). Lymphocyte count is currently recognized in certain risk stratification scores for chronic HF, and severe HF is associated with lymphocytopenia. However, no data exists on the association between lymphocyte count and functional capacity in patients with stable HF. This study aimed to assess the relationship between lymphocyte count and New York Heart Association (NYHA) functional capacity in systolic HF outpatients.

METHODS
The Turkish Research Team-HF (TREAT-HF) is a network which undertakes multi-center observational studies in HF. Data on 392 HF reduced ejection fraction (HFREF) patients from 8 HF centers are presented here. The patients were divided into two groups and compared: Group 1 comprised stable HFREF patients with mild symptoms (NYHA Class I-II), while Group 2 consisted of patients with NYHA Class III-IV symptoms.

RESULTS
Patient mean age was 60±14 years. Lymphocyte count was lower in patients with NYHA functional classes III and IV than in patients with NYHA functional classes I and II, (0.9 [0.6–1.5] x1000 versus 1.5 [0.7–2.2] x1000, p<0.001). In multivariate logistic regression analysis, lymphocyte count (OR: 0.602, 95% CI: 0.375–0.967, p=0.036), advanced age, male gender, presence of hypertension, EF, left atrium size, systolic pulmonary artery pressure, neutrophil and basophil counts, creatinine level, and diuretic usage were associated with poor NYHA functional class in systolic HF outpatients.

CONCLUSION
The present study demonstrated that in stable HFREF outpatients, lymphocytopenia was strongly associated with poor NYHA function, independent of coronary heart disease risk factors.

Keywords: Heart failure, lymphocyte; lymphocytopenia; NYHA functional class

How to cite this article
Hasan Yucel, Meltem Refiker Ege, Ali Zorlu, Hakki Kaya, Osman Beton, Hasan Gungor, Gurkan Acar, Ahmet Temizhan, Yüksel Çavuşoğlu, Mehdi Zoghi, Mehmet Eren, Dilek Ural, Mehmet Birhan Yilmaz. Lymphocytopenia is associated with poor NYHA functional class in chronic heart failure patients with reduced ejection fraction. Turk Kardiyol Dern Ars. 2015; 43(5): 427-433

Corresponding Author: Hasan Yucel, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
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0.22
SCImago Journal Rank: 0.348

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