ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Efficacy and benefits of catheter ablation of premature ventricular complexes in patients younger and older than sixty-five years of age [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2013; 41(6): 497-504 | DOI: 10.5543/tkda.2013.77503

Efficacy and benefits of catheter ablation of premature ventricular complexes in patients younger and older than sixty-five years of age

Mehmet Akkaya1, Henri Roukoz1, Selcuk Adabag2, Andrew Peter1, Jian Ming Li2, Venkat Tholakanahalli2
1University Minnesota Medical Center, Cardiovascular Division, Minneapolis, Minnesota,usa
2Minneapolis VA Medical Center, Cardiovascular Division, Minneapolis, Minnesota,usa


OBJECTIVES
Catheter ablation of premature ventricular complexes (PVC) improves clinical status and systolic performance of left ventricle (LV) in certain subset of patients, however whether PVC ablation is equally effective in younger (≤65 years old) and older (>65 years) patients remain unclear. We aimed to assess clinical benefits of catheter ablation of PVCs in elderly patients.

METHODS
Fifty-one consecutive patients (66±10 years, 49 male) who underwent catheter ablation for symptomatic PVCs were included into the study. Twenty-seven patients were aged>65 years and 24 patients ≤65 years old. Frequency of PVCs per total heart beats by 24-hour Holter monitoring, LV ejection fraction (LVEF) and end-systolic diameters (LVEDD) were evaluated before and 6±3 months after ablation.

RESULTS
The pre-ablation 24 hour PVC burden and PVC number was significantly higher in patients aged >65 years old compared aged ≤65 years (31±15.3 vs. 21.9±12.6; p = 0.04 and 34493±21226 vs. 23554±13792; p = 0.026, respectively). At follow up after catheter ablation, the mean PVC burden decreased to 9.1±10.3% (p<0.001) in patients >65 years while to 3.8±7.1 (p<0.001) in patients ≤65 years of age. Mean LVEF showed significant increase in both groups after ablation (43.4±10.4 vs. 51.5±8.2; p = 0.005 for age>65 years and 40.8±13.2 vs. 49.5±11.8; p = 0.003 for age ≤65 years). The improvement in LVEF was accompanied by significant decrease in LV end-diastolic diameter (p = 0.032 for age>65 and p = 0.047 for ≤65 years).

CONCLUSION
Catheter ablation is effective for treatment of frequent PVCs in all age groups.

Keywords: premature ventricular complexes, catheter ablation, elderly, echocardiography, left ventricle

How to cite this article
Mehmet Akkaya, Henri Roukoz, Selcuk Adabag, Andrew Peter, Jian Ming Li, Venkat Tholakanahalli. Efficacy and benefits of catheter ablation of premature ventricular complexes in patients younger and older than sixty-five years of age. Turk Kardiyol Dern Ars. 2013; 41(6): 497-504

Corresponding Author: Mehmet Akkaya, United States
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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