Archives of the Turkish Society of Cardiology
The relationship between orthostatic differences in arterial blood pressure and autonomic tone: gender variability [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2007; 35(2): 69-77

The relationship between orthostatic differences in arterial blood pressure and autonomic tone: gender variability

Tolga Doğru1, Serdar Günaydın2, Vedat Şimşek1, Murat Tulmaç2, Emine Tireli1
1Department Of Cardiology, University Of Kirikkale, Kirikkale, Turkey
2Department Of Cardiovascular Surgery, University Of Kirikkale, Kirikkale, Turkey


OBJECTIVES
The differences in orthostatic blood pressure result from dynamic changes in the sympathovagal balance. We studied sex-related variations in autonomic tone regulation.

STUDY DESIGN
The study included 237 individuals (114 males, 123 females) who were asymptomatic and had no abnormal laboratory or physical findings. The mean age was 47 years (range 20 to 79 years) for men, and 39 years (range 20 to 71 years) for women. All the participants were subjected to a careful history taking, physical examination, routine biochemical examinations, electrocardiographic recording, 24-hour Holter monitoring, and orthostatic tests.

RESULTS
In heart rate variability analysis, parasympathetic tone parameters, in particular the high frequency (HF) component was significantly high in females, whereas sympathetic tone parameters, in particular the low frequency (LF)/HF ratio was significantly high in males (p<0.001). The normalized LF component in males showed positive correlations with systolic (r=0.308, p=0.001) and diastolic (r=0.301, p=0.002) blood pressures during the rapid stand test; this correlation was not seen in females. Blood pressures obtained in the second minute of the rapid supine test following the stand test were in positive correlation with the LF/HF ratio in both sexes. In males, variations in systolic and diastolic blood pressures during rest, stand, and supine positions were primarily influenced by the LF component and HF component, respectively. In females, variations in systolic blood pressure during the three positions were not correlated with autonomic tone components, but variations in diastolic blood pressure were primarily affected by the LF/HF ratio.

CONCLUSION
Autonomic system works through varying priorities in both sexes and this causes sex-related differences in orthostatic tolerance.

Keywords: Autonomic nervous system, blood pressure, heart rate, posture/physiology; sex characteristics

How to cite this article
Tolga Doğru, Serdar Günaydın, Vedat Şimşek, Murat Tulmaç, Emine Tireli. The relationship between orthostatic differences in arterial blood pressure and autonomic tone: gender variability. Turk Kardiyol Dern Ars. 2007; 35(2): 69-77

Corresponding Author: Tolga Doğru, Türkiye
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