Variation of Computed Tomography Derived Fractional Flow Reserve (FFRCT) Related to Different Vessel Morphology

A total of 1492 outpatients with suspected coronary artery disease and who underwent computed tomography derived fractional flow reserve (FFRCT) analysis were examined. To investigate the effects of vessel morphology such as lumen diameter or volume on FFRCT, nearly the same or subthreshold values affecting FFRCT hemodynamics vessels were compared. Case 1 and two present almost the same vessel length (Case 1 vs. Case 2; 135.0 mm vs. 133.6 mm), low-attenuation plaque volume (0 mm3 vs. 0 mm3), intermediate-attenuation plaque volume (12.5 mm3 vs. 35.5 mm3), and calcified plaque volume (4.7 mm3 vs. 0 mm3) in the right coronary artery. However, lumen volume (877.8 mm3 vs. 2443.7 mm3) and distal FFRCT (0.79 vs. 0.96) were markedly different between the two patients. FFRCT depends not only on vessel length or plaque characteristics but also on lumen volume or vessel morphology.